rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
2004-8-3
|
pubmed:abstractText |
This study was conducted to investigate the anti-proliferative activities of medicinal mushroom Ganoderma lucidum (Rei-shi or Mannentake). We have identified an alcohol extract from the spore of Ganoderma lucidum that inhibits the in vitro proliferation of human umbilical vein endothelial cells and MDA-MB231 human breast cancer cells. Further fractionation of the alcohol extract revealed that the ethyl acetate fraction inhibited both cell lines in a dose-dependent manner from 2 to 40 micro g/ml. Our results suggest that the alcohol extract from the spore of Ganoderma lucidum may possess potential anti-tumor and anti-angiogenic activities.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
1021-335X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
12
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
659-62
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:15289852-Angiogenesis Inhibitors,
pubmed-meshheading:15289852-Antineoplastic Agents,
pubmed-meshheading:15289852-Breast Neoplasms,
pubmed-meshheading:15289852-Cell Division,
pubmed-meshheading:15289852-Cell Line, Tumor,
pubmed-meshheading:15289852-Cells, Cultured,
pubmed-meshheading:15289852-Chromatography,
pubmed-meshheading:15289852-Dose-Response Relationship, Drug,
pubmed-meshheading:15289852-Drugs, Chinese Herbal,
pubmed-meshheading:15289852-Endothelial Cells,
pubmed-meshheading:15289852-Ethanol,
pubmed-meshheading:15289852-Humans,
pubmed-meshheading:15289852-Plant Extracts,
pubmed-meshheading:15289852-Reishi,
pubmed-meshheading:15289852-Spores, Fungal,
pubmed-meshheading:15289852-Umbilical Veins
|
pubmed:year |
2004
|
pubmed:articleTitle |
Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro.
|
pubmed:affiliation |
Department of Medicine, Center for Human Nutrition, University of California-Los Angeles, Los Angeles, CA 90095, USA.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|