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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-8-3
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pubmed:abstractText |
Cytochrome P450 (CYP) 1A2 activity is induced by cigarette smoking. Thus smoking cessation in patients while they are undergoing therapy with a CYP1A2 substrate such as theophylline or clozapine increases its concentrations and may cause adverse effects. Our objective was to determine the time course of CYP1A2 activity changes after smoking cessation in heavy smokers as the basis for dosing adaptation schemes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0009-9236
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
178-84
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15289794-Adult,
pubmed-meshheading:15289794-Biological Availability,
pubmed-meshheading:15289794-Caffeine,
pubmed-meshheading:15289794-Central Nervous System Stimulants,
pubmed-meshheading:15289794-Confidence Intervals,
pubmed-meshheading:15289794-Cytochrome P-450 CYP1A2,
pubmed-meshheading:15289794-Female,
pubmed-meshheading:15289794-Half-Life,
pubmed-meshheading:15289794-Humans,
pubmed-meshheading:15289794-Linear Models,
pubmed-meshheading:15289794-Male,
pubmed-meshheading:15289794-Metabolic Clearance Rate,
pubmed-meshheading:15289794-Probability,
pubmed-meshheading:15289794-Sampling Studies,
pubmed-meshheading:15289794-Smoking,
pubmed-meshheading:15289794-Smoking Cessation,
pubmed-meshheading:15289794-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Time response of cytochrome P450 1A2 activity on cessation of heavy smoking.
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pubmed:affiliation |
Department of Pharmacology, Clinical Pharmacology, University of Cologne, Köln, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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