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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1992-10-22
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pubmed:abstractText |
Agents that inhibit nitric oxide synthesis augment hypoxic pulmonary vasoconstriction. In an animal model of unilateral alveolar hypoxia, we investigated the hypothesis that endogenous endothelium-derived relaxing factor/nitric oxide opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli, resulting in a reduction in arterial oxygen tension (PO2). In pentobarbital-anesthetized rabbits, unilateral alveolar hypoxia was produced by ventilation of one lung with 100% oxygen and the other with 100% nitrogen (O2/N2). NG-Nitro-L-arginine methyl ester (0.03 followed by 1.0 mg/kg i.v.) resulted in dose-dependent decreases in the percent of pulmonary blood flow to the N2-ventilated lung and increases in arterial PO2. L-Arginine (1 mg.kg-1.min-1 i.v.) prevented the NG-nitro-L-arginine methyl ester-induced redistribution of blood flow away from hypoxic alveoli and improvement in arterial PO2. Indomethacin (5 mg/kg i.v.) administered during O2/N2 ventilation resulted in a reduction in the percentage of total blood flow to the hypoxic lung and an increase in arterial PO2. However, NG-nitro-L-arginine methyl ester administered in the presence of indomethacin caused additional diversion of blood flow away from the hypoxic lung. The magnitude of the changes suggests that the endothelium-derived relaxing factor/nitric oxide system has the capacity to make a greater contribution than products of cyclooxygenase-mediated arachidonic acid metabolism in supporting blood flow to hypoxic alveoli in the rabbit.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-1707210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-1986681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-2076481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-2156794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-2159226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-2236071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-2322257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-2328404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-2480112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-2555077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-2605870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-2708229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-2890446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-3135198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-3263394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-3495737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-453573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-6373692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-6584596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-6798221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1528883-76024
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8711-5
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1528883-Animals,
pubmed-meshheading:1528883-Anoxia,
pubmed-meshheading:1528883-Arginine,
pubmed-meshheading:1528883-Indomethacin,
pubmed-meshheading:1528883-Male,
pubmed-meshheading:1528883-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:1528883-Nitric Oxide,
pubmed-meshheading:1528883-Pulmonary Alveoli,
pubmed-meshheading:1528883-Pulmonary Circulation,
pubmed-meshheading:1528883-Rabbits,
pubmed-meshheading:1528883-Regional Blood Flow,
pubmed-meshheading:1528883-Vasoconstriction
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pubmed:year |
1992
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pubmed:articleTitle |
Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits.
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pubmed:affiliation |
William Harvey Research Institute, St. Bartholomew's Hospital Medical College, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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