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pubmed-article:15288742pubmed:abstractTextThe borders of Thailand harbour the world's most multidrug resistant Plasmodium falciparum parasites. In 1984 mefloquine was introduced as treatment for uncomplicated falciparum malaria, but substantial resistance developed within 6 years. A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known.lld:pubmed
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pubmed-article:15288742pubmed:articleTitleMefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number.lld:pubmed
pubmed-article:15288742pubmed:affiliationDepartment of Cellular and Molecular Medicine-Infectious Diseases, St George's Hospital Medical School, London, UK.lld:pubmed
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