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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9432
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pubmed:dateCreated |
2004-8-3
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pubmed:abstractText |
The borders of Thailand harbour the world's most multidrug resistant Plasmodium falciparum parasites. In 1984 mefloquine was introduced as treatment for uncomplicated falciparum malaria, but substantial resistance developed within 6 years. A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Antimalarials,
http://linkedlifedata.com/resource/pubmed/chemical/Artemisinins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Transporting ATPases,
http://linkedlifedata.com/resource/pubmed/chemical/Codon,
http://linkedlifedata.com/resource/pubmed/chemical/Mefloquine,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PfCRT protein, Plasmodium falciparum,
http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sesquiterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/artesunate,
http://linkedlifedata.com/resource/pubmed/chemical/mdr gene protein, Plasmodium
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pubmed:status |
MEDLINE
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pubmed:issn |
1474-547X
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pubmed:author |
pubmed-author:AshleyElizabethE,
pubmed-author:BrockmanAlanA,
pubmed-author:KrishnaSanjeevS,
pubmed-author:LaingKennethK,
pubmed-author:LooareesuwanSornchaiS,
pubmed-author:McGreadyRoseR,
pubmed-author:NostenFrançoisF,
pubmed-author:PatelRinaR,
pubmed-author:PhaipunLucyL,
pubmed-author:UhlemannAnne-CatrinAC,
pubmed-author:WARDA FAFJr,
pubmed-author:WhiteNicholas JNJ
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pubmed:issnType |
Electronic
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pubmed:volume |
364
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
438-47
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15288742-ATP-Binding Cassette Transporters,
pubmed-meshheading:15288742-Adolescent,
pubmed-meshheading:15288742-Adult,
pubmed-meshheading:15288742-Aged,
pubmed-meshheading:15288742-Aged, 80 and over,
pubmed-meshheading:15288742-Animals,
pubmed-meshheading:15288742-Antimalarials,
pubmed-meshheading:15288742-Artemisia,
pubmed-meshheading:15288742-Artemisinins,
pubmed-meshheading:15288742-Calcium-Transporting ATPases,
pubmed-meshheading:15288742-Child,
pubmed-meshheading:15288742-Child, Preschool,
pubmed-meshheading:15288742-Codon,
pubmed-meshheading:15288742-Drug Resistance,
pubmed-meshheading:15288742-Drug Therapy, Combination,
pubmed-meshheading:15288742-Female,
pubmed-meshheading:15288742-Gene Dosage,
pubmed-meshheading:15288742-Genes, MDR,
pubmed-meshheading:15288742-Genotype,
pubmed-meshheading:15288742-Humans,
pubmed-meshheading:15288742-Malaria, Falciparum,
pubmed-meshheading:15288742-Male,
pubmed-meshheading:15288742-Mefloquine,
pubmed-meshheading:15288742-Membrane Proteins,
pubmed-meshheading:15288742-Membrane Transport Proteins,
pubmed-meshheading:15288742-Middle Aged,
pubmed-meshheading:15288742-Plasmodium falciparum,
pubmed-meshheading:15288742-Polymorphism, Genetic,
pubmed-meshheading:15288742-Polymorphism, Single Nucleotide,
pubmed-meshheading:15288742-Protozoan Proteins,
pubmed-meshheading:15288742-Sesquiterpenes,
pubmed-meshheading:15288742-Thailand
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pubmed:articleTitle |
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number.
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pubmed:affiliation |
Department of Cellular and Molecular Medicine-Infectious Diseases, St George's Hospital Medical School, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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