Source:http://linkedlifedata.com/resource/pubmed/id/15287946
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2004-8-3
|
| pubmed:abstractText |
The present study investigated the effects of CD34(+) cell selection in 102 patients using the CliniMACS device. Patients were at high risk for the development of graft versus host disease (GvHD) because of age, or the use of a haploidentical, mismatched or unrelated donor (UD). The median age of the patients was 44 years. The CliniMACS procedure yielded 8.0 x 10(6) CD34(+) cells/kg and the number of residual T cells was 1.3 x 10(4)/kg (median). The median follow up was 20.6 months. The probability of graft failure was 7%. The rate of acute GvHD was low (compatible family donors 10%, UDs 17%, and haploidentical donors 26%) with no patient enduring more than grade II disease. The cumulative incidence of chronic GvHD at the median follow up after transplant was 15% for the compatible family donor group, 40% for the UD group and 78% in the group transplanted from a haploidentical donor Treatment failure was mainly because of transplant-related mortality, especially aspergillus infection, and not due to relapse. The probability of disease-free survival, stratified for the risk of treatment failure, was 27% for the high risk, 46% for the intermediate risk and 83% for the low risk group.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0007-1048
|
| pubmed:author |
pubmed-author:BunjesDonaldD,
pubmed-author:DöhnerHartmutH,
pubmed-author:GrimmingerWolfgangW,
pubmed-author:HarsdorfStephanieS,
pubmed-author:MertensThomasT,
pubmed-author:MoessnerMargitM,
pubmed-author:ReinhardtPeter PPP,
pubmed-author:ReskeSven NSN,
pubmed-author:RinghofferMarkM,
pubmed-author:SchlenkRichard FRF,
pubmed-author:SchmittAnitaA,
pubmed-author:WiesnethMarkusM
|
| pubmed:issnType |
Print
|
| pubmed:volume |
126
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
527-35
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15287946-Acute Disease,
pubmed-meshheading:15287946-Adolescent,
pubmed-meshheading:15287946-Adult,
pubmed-meshheading:15287946-Antigens, CD34,
pubmed-meshheading:15287946-Cell Separation,
pubmed-meshheading:15287946-Chronic Disease,
pubmed-meshheading:15287946-Disease-Free Survival,
pubmed-meshheading:15287946-Female,
pubmed-meshheading:15287946-Follow-Up Studies,
pubmed-meshheading:15287946-Graft Survival,
pubmed-meshheading:15287946-Graft vs Host Disease,
pubmed-meshheading:15287946-Hematologic Neoplasms,
pubmed-meshheading:15287946-Histocompatibility Testing,
pubmed-meshheading:15287946-Humans,
pubmed-meshheading:15287946-Male,
pubmed-meshheading:15287946-Middle Aged,
pubmed-meshheading:15287946-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:15287946-Survival Analysis,
pubmed-meshheading:15287946-Tissue and Organ Harvesting,
pubmed-meshheading:15287946-Transplantation Chimera,
pubmed-meshheading:15287946-Transplantation Conditioning
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
CD34 cell selection of peripheral blood progenitor cells using the CliniMACS device for allogeneic transplantation: clinical results in 102 patients.
|
| pubmed:affiliation |
Department of Internal Medicine III, University of Ulm, Ulm, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
|