Linked Life Data

15286456

Source:http://linkedlifedata.com/resource/pubmed/id/15286456

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2004-10-1
pubmed:abstractText
An increasing number of studies suggest that cholesterol plays an important role in regulating beta-amyloid (Abeta) metabolism in Alzheimer's disease (AD). One of the most important mechanisms for the elimination of excess brain cholesterol is its conversion into the 24S-hydroxycholesterol catalyzed by cholesterol 24S-hydroxylase (CYP46). Preliminary evidence indicates that an intron 2 CYP46 T/C gene polymorphismis associated with increased brain Abeta load and higher risk of AD. A case-control study utilizing a clinically well-defined group of 321 sporadic AD patients and 315 control subjects was performed to test this association. Our results indicate that the intron 2 CYP46 C/C genotype may predispose to AD, and this association is independent of the apolipoprotein E genotype.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1420-8008
pubmed:author
pubmed:copyrightInfo
2004 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-60
pubmed:dateRevised
2008-3-24
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Genetic association of CYP46 and risk for Alzheimer's disease.
pubmed:affiliation
Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria), Santander, Spain. combarro@unican.es
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't