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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1992-10-20
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pubmed:abstractText |
Adult T cell leukemia/lymphoma (ATLL) induced by human T cell leukemia virus I is resistant to conventional therapy. Six patients with ATLL were treated with a new antitumor agent, MST-16, which is a derivative of bis(2,6-dioxopiperazine). Two patients achieved complete remission, lasting 12 months and more than 8 months, and 2 others partial remission, lasting 2 months and 6 weeks, respectively. The major toxicity was myelosuppression. Other toxicities were not severe and were well tolerable. Orally administered MST-16 is a promising agent for the treatment of ATLL.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0030-2414
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
49
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
333-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1528567-Administration, Oral,
pubmed-meshheading:1528567-Adult,
pubmed-meshheading:1528567-Aged,
pubmed-meshheading:1528567-Antineoplastic Agents,
pubmed-meshheading:1528567-Drug Evaluation,
pubmed-meshheading:1528567-Female,
pubmed-meshheading:1528567-Humans,
pubmed-meshheading:1528567-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:1528567-Male,
pubmed-meshheading:1528567-Piperazines
|
pubmed:year |
1992
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pubmed:articleTitle |
Effective treatment of adult T cell leukemia/lymphoma with a novel oral antitumor agent, MST-16.
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pubmed:affiliation |
Department of Medicine, Branch Hospital, Nagoya University School of Medicine, Japan.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|