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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-8-2
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pubmed:abstractText |
Uterine papillary serous adenocarcinoma (UPSC) is an uncommon histologic subtype of endometrial cancer that characteristically behaves aggressively with a poor prognosis. We established two novel cell lines derived from UPSC designated HEC-155 and HEC-180. Both cell lines have been growing steadily in monolayer cultures for over ten years. Overexpression of p53, Ki67 and p27 was detected in both cell lines by immunohistochemistry. Using a DNA sequencing technique, a point mutation of p53 was detected in exon 8, codon 286 in HEC-155 and in exon 6, codon 195 in HEC-180. These newly established cell lines should be useful for investigating the characteristics of UPSC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0392-2936
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pubmed:author |
pubmed-author:AraiTT,
pubmed-author:HamanoMM,
pubmed-author:HataHH,
pubmed-author:HayashiKK,
pubmed-author:IshizukaBB,
pubmed-author:KawaguchiMM,
pubmed-author:KiguchiKK,
pubmed-author:KuramotoHH,
pubmed-author:MANNS JSJ,
pubmed-author:NishimuraYY,
pubmed-author:WatanabeJJ,
pubmed-author:YonamineKK,
pubmed-author:YoshidaNN
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
423-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15285295-Biopsy, Needle,
pubmed-meshheading:15285295-Cell Division,
pubmed-meshheading:15285295-Cell Line, Tumor,
pubmed-meshheading:15285295-Cystadenocarcinoma, Papillary,
pubmed-meshheading:15285295-Female,
pubmed-meshheading:15285295-Humans,
pubmed-meshheading:15285295-Immunohistochemistry,
pubmed-meshheading:15285295-Karyotyping,
pubmed-meshheading:15285295-Middle Aged,
pubmed-meshheading:15285295-Mutation,
pubmed-meshheading:15285295-Sensitivity and Specificity,
pubmed-meshheading:15285295-Transplantation, Heterologous,
pubmed-meshheading:15285295-Tumor Suppressor Protein p53,
pubmed-meshheading:15285295-Uterine Neoplasms
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pubmed:year |
2004
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pubmed:articleTitle |
Establishment and characterization of two cell lines (HEC-155, HEC-180) derived from uterine papillary serous adenocarcinoma.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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