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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-7-30
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF481810,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY273792,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY282534,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY282535,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY282537,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY282538,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY282539,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY282541,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY282542,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY326394,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY345903
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pubmed:abstractText |
Polymorphisms in UDP-glucuronosyltransferases (UGTs) can influence detoxifying capacities and have considerable therapeutic implications in addition to influence various (patho)physiological processes. UGT1A9 plays a central role in the metabolism of various classes of therapeutic drugs in addition to carcinogens and steroids. The great interindividual variability of UGT1A9-mediated glucuronidation remains poorly explained, while evidence for its genetic origin exists.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-314X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
501-15
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15284532-Adolescent,
pubmed-meshheading:15284532-Adult,
pubmed-meshheading:15284532-African Americans,
pubmed-meshheading:15284532-Aged,
pubmed-meshheading:15284532-Base Sequence,
pubmed-meshheading:15284532-Child,
pubmed-meshheading:15284532-Child, Preschool,
pubmed-meshheading:15284532-European Continental Ancestry Group,
pubmed-meshheading:15284532-Female,
pubmed-meshheading:15284532-Genotype,
pubmed-meshheading:15284532-Glucuronates,
pubmed-meshheading:15284532-Glucuronosyltransferase,
pubmed-meshheading:15284532-Haplotypes,
pubmed-meshheading:15284532-Humans,
pubmed-meshheading:15284532-Male,
pubmed-meshheading:15284532-Microsomes, Liver,
pubmed-meshheading:15284532-Middle Aged,
pubmed-meshheading:15284532-Molecular Sequence Data,
pubmed-meshheading:15284532-Polymorphism, Single Nucleotide,
pubmed-meshheading:15284532-Promoter Regions, Genetic
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pubmed:year |
2004
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pubmed:articleTitle |
Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.
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pubmed:affiliation |
Canada Research Chair in Pharmacogenomics, Laboratory of Pharmacogenomics, Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Faculty of Pharmacy, Laval University, Québec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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