Source:http://linkedlifedata.com/resource/pubmed/id/15281018
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2004-7-28
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| pubmed:abstractText |
Uncoupling protein-1 (UCP-1) plays a major role in thermogenesis, and has been implicated in the pathogenesis of obesity and metabolic disorders. The purpose of this study was to estimate the effects of A-3826G polymorphism of the UCP-1 gene on the plasma lipid profiles in 190 Korean obese subjects with a body mass index (BMI) more than 30 kg/m2. Height, weight, BMI, wait-to-hip ratio (WHR), obesity index, and body composition were measured and genotype of UCP-1 was analyzed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method. Serum concentrations of fasting glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride were measured. The frequencies of UCP-1 genotypes were AA type, 22.1%; AG type, 53.7%; and GG type, 24.2%; and the frequency of G allele was 0.51. Among many parameters, diastolic blood pressure (DBP) (P = .023) and low-density lipoprotein (LDL) cholesterol (P = .011) were significantly higher in AG and GG types compared with AA type, whereas HDL cholesterol was significantly lower in GG type compared with other types (P < .05). Atherogenic index was significantly higher in GG type compared with AA type (P = 0.027). LDL-to-HDL cholesterol ratio was significantly increased in the order of AA < AG < GG types (P = .001). When the subjects were divided into a normal group and a hyper-LDL cholesterolemia group by LDL cholesterol level of 3.626 mmol/L (140 mg/dL), the frequency of hyper-LDL cholesterolemia was significantly higher in GG type compared with other types by Fisher's exact (chi-square) test (P = .05). When logistic regression analysis was conducted to find the risk factors of hyper-LDL cholesterolemia, the odds ratio was 4.115 (P = .03) for GG type of UCP-1 gene. These results suggest that the GG type of the UCP-1 gene has a strong association with increased LDL cholesterol level and might be a significant risk factor for hyper-LDL cholesterolemia among Korean obese subjects.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0026-0495
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2004 Elsevier Inc.
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| pubmed:issnType |
Print
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| pubmed:volume |
53
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1054-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15281018-Adult,
pubmed-meshheading:15281018-Blood Glucose,
pubmed-meshheading:15281018-Blood Pressure,
pubmed-meshheading:15281018-Body Composition,
pubmed-meshheading:15281018-Body Mass Index,
pubmed-meshheading:15281018-Body Weight,
pubmed-meshheading:15281018-Carrier Proteins,
pubmed-meshheading:15281018-Cholesterol,
pubmed-meshheading:15281018-Cholesterol, HDL,
pubmed-meshheading:15281018-Cholesterol, LDL,
pubmed-meshheading:15281018-Female,
pubmed-meshheading:15281018-Gene Frequency,
pubmed-meshheading:15281018-Genotype,
pubmed-meshheading:15281018-Humans,
pubmed-meshheading:15281018-Hypercholesterolemia,
pubmed-meshheading:15281018-Ion Channels,
pubmed-meshheading:15281018-Korea,
pubmed-meshheading:15281018-Lipoproteins,
pubmed-meshheading:15281018-Liver Function Tests,
pubmed-meshheading:15281018-Logistic Models,
pubmed-meshheading:15281018-Male,
pubmed-meshheading:15281018-Membrane Proteins,
pubmed-meshheading:15281018-Mitochondrial Proteins,
pubmed-meshheading:15281018-Obesity,
pubmed-meshheading:15281018-Polymorphism, Genetic
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| pubmed:year |
2004
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| pubmed:articleTitle |
The effects of uncoupling protein-1 genotype on lipoprotein cholesterol level in Korean obese subjects.
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| pubmed:affiliation |
Medical R&D Department, Korea Institute of Oriental Medicine, Taejon, South Korea.
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| pubmed:publicationType |
Journal Article
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