15280505

Source:http://linkedlifedata.com/resource/pubmed/id/15280505

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0019693, umls-concept:C0024296, umls-concept:C0449822
pubmed:issue	16
pubmed:dateCreated	2004-7-28
pubmed:abstractText	Human immunodeficiency virus type 1 (HIV-1)-infected splenocytes in humans were recently shown to harbor three to four proviruses per cell on average (A. Jung et al., Nature 418:144, 2002). However, the mechanisms that lead to such extensive multiple infections are not understood. Here, we find by using mathematical analysis that two mechanisms quantitatively capture the distribution of proviral genomes in HIV-1-infected splenocytes, one where multiple genomes are acquired one at a time in a series of sequential infectious contacts of a target cell with free virions and infected cells, and the other where cell-to-cell transmission of multiple virions or genomes results from a single infectious contact of a target cell with an infected cell. The two mechanisms imply different genetic diversities of proviruses within an infected cell and therefore different rates of emergence of drug resistance via recombination.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AI28433, http://linkedlifedata.com/resource/pubmed/grant/RR06555
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/15280505-10199403, http://linkedlifedata.com/resource/pubmed/commentcorrection/15280505-10358770, http://linkedlifedata.com/resource/pubmed/commentcorrection/15280505-12110879, http://linkedlifedata.com/resource/pubmed/commentcorrection/15280505-12601158, http://linkedlifedata.com/resource/pubmed/commentcorrection/15280505-12947040, http://linkedlifedata.com/resource/pubmed/commentcorrection/15280505-1370739, http://linkedlifedata.com/resource/pubmed/commentcorrection/15280505-14707263, http://linkedlifedata.com/resource/pubmed/commentcorrection/15280505-15010526, http://linkedlifedata.com/resource/pubmed/commentcorrection/15280505-8096155, http://linkedlifedata.com/resource/pubmed/commentcorrection/15280505-8599114, http://linkedlifedata.com/resource/pubmed/commentcorrection/15280505-8709227
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0113724
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0022-538X
pubmed:author	pubmed-author:DixitNarendra MNM, pubmed-author:PerelsonAlan SAS
pubmed:issnType	Print
pubmed:volume	78
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	8942-5
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:15280505-HIV Infections, pubmed-meshheading:15280505-HIV-1, pubmed-meshheading:15280505-Humans, pubmed-meshheading:15280505-Lymphoid Tissue, pubmed-meshheading:15280505-Models, Biological, pubmed-meshheading:15280505-Proviruses, pubmed-meshheading:15280505-Spleen
pubmed:year	2004
pubmed:articleTitle	Multiplicity of human immunodeficiency virus infections in lymphoid tissue.
pubmed:affiliation	MS K710, T-10, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.