|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16
|
|
pubmed:dateCreated |
2004-7-28
|
|
pubmed:abstractText |
Although Japan is classified as a country with a low prevalence of human immunodeficiency virus type 1 (HIV-1), domestic sexual transmission has been increasing steadily. Because 70% of the Japanese population expresses HLA-A24 (genotype HLA-A*2402), we wished to assess the effect of the dominant HLA type on the evolution and transmission of HIV-1 among the Japanese population. Twenty-three out of 25 A24-positive Japanese patients had a Y-to-F substitution at the second position [Nef138-10(2F)] in an immunodominant A24-restricted CTL epitope in their HIV-1 nef gene (Nef138-10). None of 12 A24-negative Japanese hemophiliacs but 9 out of 16 patients infected through unprotected sexual intercourse had Nef138-10(2F) (P < 0.01). Two of two A24-positive but none of six A24-negative Australians had Nef138-10(2F). Nef138-10(2F) peptides bound well to the HLA-A*2402 heavy chain; however, Nef138-10(2F) was expressed poorly on the cell surface from the native protein. Thus, HIV-1 with Nef138-10(2F) appears to be a cytotoxic-T-lymphocyte escape mutant and has been transmitted frequently by sexual contact among the highly A24-positive Japanese population.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-10461830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-10657639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-11242051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-11371685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-11460164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-11535524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-11884484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-11927944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-11983929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-11984594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-12029127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-12097566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-12213944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-12368910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-12414940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-12502873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-12819779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-14508489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-14508490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-1721107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-2420768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-2744487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-7520468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-7682013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-8057491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-8207839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-8612235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-9018240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-9018241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-9143689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-9412709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-9450757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-9516110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15280452-9550428
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-538X
|
|
pubmed:author |
pubmed-author:CooperDavid ADA,
pubmed-author:FurutsukiTaeT,
pubmed-author:GotoMiekoM,
pubmed-author:HosoyaNoriakiN,
pubmed-author:IwamotoAikichiA,
pubmed-author:Kawana-TachikawaAiA,
pubmed-author:KelleherAnthony DAD,
pubmed-author:KitamuraYoshihiroY,
pubmed-author:NakamuraTetsuyaT,
pubmed-author:OdawaraTakashiT,
pubmed-author:TomizawaMarikoM
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
78
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
8437-45
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:15280452-Amino Acid Sequence,
pubmed-meshheading:15280452-Amino Acid Substitution,
pubmed-meshheading:15280452-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:15280452-Epitopes, T-Lymphocyte,
pubmed-meshheading:15280452-Gene Products, nef,
pubmed-meshheading:15280452-HIV Infections,
pubmed-meshheading:15280452-HIV-1,
pubmed-meshheading:15280452-HLA-A Antigens,
pubmed-meshheading:15280452-HLA-A24 Antigen,
pubmed-meshheading:15280452-Hemophilia A,
pubmed-meshheading:15280452-Humans,
pubmed-meshheading:15280452-Immunodominant Epitopes,
pubmed-meshheading:15280452-Japan,
pubmed-meshheading:15280452-Male,
pubmed-meshheading:15280452-Molecular Sequence Data,
pubmed-meshheading:15280452-Sexually Transmitted Diseases, Viral,
pubmed-meshheading:15280452-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:15280452-nef Gene Products, Human Immunodeficiency Virus
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Frequent transmission of cytotoxic-T-lymphocyte escape mutants of human immunodeficiency virus type 1 in the highly HLA-A24-positive Japanese population.
|
|
pubmed:affiliation |
Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
