Linked Life Data

15280194

Source:http://linkedlifedata.com/resource/pubmed/id/15280194

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2004-11-4
pubmed:abstractText
Administration of exogenous interleukin-18 (IL-18) regulates experimental acute graft-versus-host disease (GVHD) in a Fas-dependent manner when donor CD4(+) T cells are required for mortality after experimental allogeneic bone marrow transplantation (BMT). However, CD4(+) and CD8(+) T cells can induce acute GVHD after clinical allogeneic BMT, and the role of IL-18 in CD8(+)-mediated acute GVHD is unknown. We, therefore, determined the role of IL-18 in GVHD mediated by CD4(+) or CD8(+) T cells across major histocompatibility complex (MHC) class II- and class I-disparate allogeneic BMT, respectively. Administering IL-18 significantly increased survival in CD4(+)-mediated GVHD but reduced survival in CD8(+)-mediated GVHD. This increase in deaths was associated with significantly greater clinical, biochemical, and histopathologic parameters of GVHD damage and was independent of Fas expression on donor T cells. Administering IL-18 significantly enhanced allospecific cytotoxic function and expansion of CD8(+) cells. Endogenous IL-18 was critical to GVHD mediated by CD8(+) donor T cells because IL-18 receptor-deficient donors caused significantly less GVHD but exacerbated CD4(+)-mediated, GVHD-related death. Furthermore, administering anti-IL-18 monoclonal antibody significantly reduced CD8(+)-mediated, GVHD-related death. Together these findings demonstrate that IL-18 has paradoxical effects on CD4(+) and CD8(+) cell-mediated GVHD.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3393-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:15280194-Acute Disease, pubmed-meshheading:15280194-Animals, pubmed-meshheading:15280194-Antibodies, Monoclonal, pubmed-meshheading:15280194-Apoptosis, pubmed-meshheading:15280194-Bone Marrow Transplantation, pubmed-meshheading:15280194-CD4-Positive T-Lymphocytes, pubmed-meshheading:15280194-CD8-Positive T-Lymphocytes, pubmed-meshheading:15280194-Cytokines, pubmed-meshheading:15280194-Disease Models, Animal, pubmed-meshheading:15280194-Female, pubmed-meshheading:15280194-Graft vs Host Disease, pubmed-meshheading:15280194-Histocompatibility Antigens Class I, pubmed-meshheading:15280194-Histocompatibility Antigens Class II, pubmed-meshheading:15280194-Interleukin-18, pubmed-meshheading:15280194-Interleukin-18 Receptor alpha Subunit, pubmed-meshheading:15280194-Mice, pubmed-meshheading:15280194-Mice, Inbred C57BL, pubmed-meshheading:15280194-Receptors, Interleukin, pubmed-meshheading:15280194-Receptors, Interleukin-18, pubmed-meshheading:15280194-Severity of Illness Index, pubmed-meshheading:15280194-T-Lymphocytes, Cytotoxic, pubmed-meshheading:15280194-Transplantation, Homologous
pubmed:year
2004
pubmed:articleTitle
Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation.
pubmed:affiliation
Department of Internal Medicine, 6310 CCGC, University of Michigan Cancer Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0942, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.