Source:http://linkedlifedata.com/resource/pubmed/id/15280193
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2004-11-19
|
| pubmed:abstractText |
Based on the hypothesis that long-term fetomaternal microchimerism is associated with acquired immunologic hyporesponsiveness to noninherited maternal antigens (NIMAs) or inherited paternal antigens (IPAs), several groups have recently reported successful cases of non-T-cell-depleted hematopoietic stem cell transplantation (SCT) from HLA-haploidentical family members mismatched for NIMAs. In this study, we examined the outcomes of 35 patients with advanced hematologic malignancies who underwent HLA-2-antigen- or HLA-3-antigen-incompatible SCT from a microchimeric NIMA-mismatched donor. After standard-intensity or reduced-intensity preparative regimens, all patients had sustained hematopoietic recovery with tacrolimus-based graft-versus-host disease (GVHD) prophylaxis. Grade II/IV acute GVHD occurred in 19 (56%) of 34 evaluable patients, while extensive chronic GVHD developed in 13 (57%) of 23 patients who could be evaluated. Multivariate analysis demonstrated that NIMA mismatch in the GVH direction was associated with a lower risk of severe grade III-IV acute GVHD when compared with IPA mismatch (P = .03). Fifteen patients were alive and 14 of them were disease-free with a median follow-up of 20 (range, 8 to 37) months. These results indicate that T cell-replete SCT from an HLA-haploidentical NIMA-mismatched donor can offer durable remission with an acceptable risk of GVHD in selected patients with advanced hematologic malignancies who lack immediate access to a conventional stem cell source.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0006-4971
|
| pubmed:author |
pubmed-author:AdachiSouichiS,
pubmed-author:FujiiHiroshiH,
pubmed-author:GondoHisashiH,
pubmed-author:HamaguchiMotohiroM,
pubmed-author:HatanakaKazuoK,
pubmed-author:HinoMasayukiM,
pubmed-author:IchinoheTatsuoT,
pubmed-author:InukaiTakeshiT,
pubmed-author:ItohBB,
pubmed-author:ItohMitsuruM,
pubmed-author:Japanese Collaborative Study Group for NIMA-Complementary...,
pubmed-author:KawaKeiseiK,
pubmed-author:KawanishiKazunobuK,
pubmed-author:KimuraHideoH,
pubmed-author:KoderaYoshihisaY,
pubmed-author:MaruyaEtsukoE,
pubmed-author:MatsuoKeitaroK,
pubmed-author:SajiHirohH,
pubmed-author:ShimazakiChihiroC,
pubmed-author:TamakiShigehisaS,
pubmed-author:UchiyamaTakashiT,
pubmed-author:UoshimaNobuhikoN,
pubmed-author:WatanabeArataA,
pubmed-author:YoshiharaTakaoT
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
104
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3821-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15280193-Adolescent,
pubmed-meshheading:15280193-Adult,
pubmed-meshheading:15280193-Cause of Death,
pubmed-meshheading:15280193-Child,
pubmed-meshheading:15280193-Child, Preschool,
pubmed-meshheading:15280193-Feasibility Studies,
pubmed-meshheading:15280193-Female,
pubmed-meshheading:15280193-Graft vs Host Disease,
pubmed-meshheading:15280193-Haplotypes,
pubmed-meshheading:15280193-Hematologic Neoplasms,
pubmed-meshheading:15280193-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:15280193-Histocompatibility,
pubmed-meshheading:15280193-Histocompatibility Testing,
pubmed-meshheading:15280193-Humans,
pubmed-meshheading:15280193-Isoantigens,
pubmed-meshheading:15280193-Male,
pubmed-meshheading:15280193-Middle Aged,
pubmed-meshheading:15280193-Mothers,
pubmed-meshheading:15280193-Nuclear Family,
pubmed-meshheading:15280193-Registries,
pubmed-meshheading:15280193-Retrospective Studies,
pubmed-meshheading:15280193-Survival Analysis,
pubmed-meshheading:15280193-Tissue Donors,
pubmed-meshheading:15280193-Transplantation Chimera
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism.
|
| pubmed:affiliation |
Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. nohe@kuhp.kyoto-u.ac.jp.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|