|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0009402,
umls-concept:C0017262,
umls-concept:C0024204,
umls-concept:C0027627,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0332281,
umls-concept:C0392756,
umls-concept:C0449258,
umls-concept:C1413274,
umls-concept:C2911684
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2004-7-28
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|
pubmed:abstractText |
Liver-intestine cadherin (LI-cadherin) is a recently identified member of the cadherin superfamily. We examined LI-cadherin expression in four human colorectal carcinoma cell lines and 45 human primary colorectal carcinomas using a monoclonal antibody against LI-cadherin. We also investigated the correlation between LI-cadherin expression and clinicopathologic parameters. Among the cell lines, LI-cadherin expression was detected in a differentiated phenotype, but not in dedifferentiated phenotypes. Among the 45 tumor samples, LI-cadherin expression was preserved in 28 (62%) and reduced in 17 (38%). Reduced LI-cadherin expression was significantly associated with a high tumor grade (P = 0.015), lymphatic invasion (P = 0.033), lymph node metastasis (P = 0.015), and an advanced pTNM stage (P = 0.033). These results suggest that analysis of LI-cadherin expression may help to indicate the biological aggressiveness of this malignancy.
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|
pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0304-3835
|
|
pubmed:author |
pubmed-author:AjiokaYoichiY,
pubmed-author:AoyagiYutakaY,
pubmed-author:GendaTakuyaT,
pubmed-author:HashimotoSatoruS,
pubmed-author:HatakeyamaKatsuyoshiK,
pubmed-author:HirohashiSetsuoS,
pubmed-author:IchidaTakafumiT,
pubmed-author:KobayashiMasaakiM,
pubmed-author:MatsudaYasunobuY,
pubmed-author:NomotoMinoruM,
pubmed-author:SakamotoMichiieM,
pubmed-author:ShiojiKazuhikoK,
pubmed-author:TakamuraMasaakiM,
pubmed-author:YamagiwaSatoshiS
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
30
|
|
pubmed:volume |
212
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
253-9
|
|
pubmed:dateRevised |
2004-12-3
|
|
pubmed:meshHeading |
pubmed-meshheading:15279905-Aged,
pubmed-meshheading:15279905-Antibodies, Monoclonal,
pubmed-meshheading:15279905-Cadherins,
pubmed-meshheading:15279905-Carcinoma,
pubmed-meshheading:15279905-Carrier Proteins,
pubmed-meshheading:15279905-Cell Differentiation,
pubmed-meshheading:15279905-Cell Line, Tumor,
pubmed-meshheading:15279905-Colorectal Neoplasms,
pubmed-meshheading:15279905-Disease Progression,
pubmed-meshheading:15279905-Female,
pubmed-meshheading:15279905-Humans,
pubmed-meshheading:15279905-Immunoblotting,
pubmed-meshheading:15279905-Immunohistochemistry,
pubmed-meshheading:15279905-Liver,
pubmed-meshheading:15279905-Lymphatic Metastasis,
pubmed-meshheading:15279905-Male,
pubmed-meshheading:15279905-Membrane Transport Proteins,
pubmed-meshheading:15279905-Middle Aged,
pubmed-meshheading:15279905-Phenotype
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma.
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|
pubmed:affiliation |
Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Japan.
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|
pubmed:publicationType |
Journal Article
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