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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-7-28
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pubmed:abstractText |
Galectins are a family of animal beta-galactoside-binding lectins involved in malignant transformation and progression. The present study evaluated the immunohistochemical expression of galectin-3 in a consecutive series of 81 radically resected non-small cell lung carcinomas (NSCLCs). The main pattern of galectin-3 expression was cytoplasmic (median percentage of cells with cytoplasmic positivity: 80.0%). The median percentage of tumor cells with nuclear and cytoplasmic co-expression of galectin-3 was 3.5%. No cases with exclusive nuclear immunostaining were observed. Functional interaction between galectin-3 and the thyroid transcription factor-1 (TTF-1) was previously demonstrated by cotransfection experiments. In the present study, concomitant expression of nuclear galectin-3 and TTF-1 was independently associated with a worse clinical outcome (HR 2.0; P = 0.01).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0304-3835
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pubmed:author |
pubmed-author:AprileGiuseppeG,
pubmed-author:BarboneFabioF,
pubmed-author:DamanteGiuseppeG,
pubmed-author:Di LoretoCarlaC,
pubmed-author:IntersimoneDonatellaD,
pubmed-author:MinisiniAlessandro MarcoAM,
pubmed-author:ParonIgorI,
pubmed-author:PigaAndreaA,
pubmed-author:PuglisiFabioF,
pubmed-author:PuppinCinziaC,
pubmed-author:TellGianlucaG
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
212
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
233-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15279903-Adenocarcinoma,
pubmed-meshheading:15279903-Adult,
pubmed-meshheading:15279903-Aged,
pubmed-meshheading:15279903-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15279903-Carcinoma, Squamous Cell,
pubmed-meshheading:15279903-Cell Nucleus,
pubmed-meshheading:15279903-Cell Transformation, Neoplastic,
pubmed-meshheading:15279903-Cytoplasm,
pubmed-meshheading:15279903-Disease Progression,
pubmed-meshheading:15279903-Female,
pubmed-meshheading:15279903-Galectin 3,
pubmed-meshheading:15279903-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15279903-Humans,
pubmed-meshheading:15279903-Immunohistochemistry,
pubmed-meshheading:15279903-Lectins,
pubmed-meshheading:15279903-Lung Neoplasms,
pubmed-meshheading:15279903-Male,
pubmed-meshheading:15279903-Middle Aged,
pubmed-meshheading:15279903-Nuclear Proteins,
pubmed-meshheading:15279903-Transcription, Genetic,
pubmed-meshheading:15279903-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Galectin-3 expression in non-small cell lung carcinoma.
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pubmed:affiliation |
Clinical Oncology, University of Udine, Italy. fabio.puglisi@med.uniud.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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