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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-7-28
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pubmed:abstractText |
The Wnt signal transduction pathway plays an important role in organogenesis and carcinogenesis. In an effort to better understand the action of oxidative stress-induced cellular signaling, we investigate the effect of exogenous H2O2 on the Wnt signal pathway. H2O2 decreases the amount of nuclear beta-catenin and Tcf/Lef-dependent transcription. Overexpression of Dvl-1 abrogated H2O2-induced downregulation of beta-catenin. Pretreatment with LiCl or Wnt-3a conditioned medium completely inhibited H2O2-induced release of mitochondrial cytochrome c and DNA fragmentation. These results suggest that H2O2 negatively modulates the Wnt signal pathway through downregulation of beta-catenin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes c,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphoid Enhancer-Binding Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/WNT3A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3A Protein,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/dishevelled proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
212
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
225-31
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15279902-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:15279902-Cell Line,
pubmed-meshheading:15279902-Cell Nucleus,
pubmed-meshheading:15279902-Culture Media, Conditioned,
pubmed-meshheading:15279902-Cytochromes c,
pubmed-meshheading:15279902-Cytoskeletal Proteins,
pubmed-meshheading:15279902-DNA Fragmentation,
pubmed-meshheading:15279902-DNA-Binding Proteins,
pubmed-meshheading:15279902-Dose-Response Relationship, Drug,
pubmed-meshheading:15279902-Down-Regulation,
pubmed-meshheading:15279902-Humans,
pubmed-meshheading:15279902-Hydrogen Peroxide,
pubmed-meshheading:15279902-Lymphoid Enhancer-Binding Factor 1,
pubmed-meshheading:15279902-Phosphoproteins,
pubmed-meshheading:15279902-Proteins,
pubmed-meshheading:15279902-Proto-Oncogene Proteins,
pubmed-meshheading:15279902-Signal Transduction,
pubmed-meshheading:15279902-Subcellular Fractions,
pubmed-meshheading:15279902-Trans-Activators,
pubmed-meshheading:15279902-Transcription, Genetic,
pubmed-meshheading:15279902-Transcription Factors,
pubmed-meshheading:15279902-Wnt Proteins,
pubmed-meshheading:15279902-Wnt3 Protein,
pubmed-meshheading:15279902-Wnt3A Protein,
pubmed-meshheading:15279902-beta Catenin
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pubmed:year |
2004
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pubmed:articleTitle |
Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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