Linked Life Data

15279587

Source:http://linkedlifedata.com/resource/pubmed/id/15279587

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-7-28
pubmed:abstractText
Immune Restoration Diseases (IRD) are a collection of atypical 'opportunistic infections' and inflammatory diseases seen in human immunodeficiency virus (HIV) patients after HIV viraemia is suppressed by highly active antiretroviral therapy (HAART). IRD probably reflect dysregulated immune responses against pre-existing infections by opportunistic pathogens, with different immunopathological mechanisms for different pathogens. For example, mycobacterial IRD are associated with delayed type hypersensitivity (DTH) responses to mycobacterial antigens, whereas patients who experience cytomegalovirus (CMV) IRD have elevated plasma levels of soluble CD30, a marker of a T2 cytokine environment expressed by activated CD8 T-cells. As IRD are often compartmentalised to organs, monitoring serological markers such as pathogen-specific IgG antibody, may be informative, as demonstrated for CMV and hepatitis C virus (HCV)-associated IRD. Genetic studies have provided evidence of distinct immunopathological mechanisms and inherited susceptibility to IRD associated with mycobacterial and herpesviridae infections. The expansion of HAART in the developing world where many HIV patients have low CD4+ T-cell counts and high rates of concomitant infections will place a large number of patients at-risk of developing IRD. It is therefore important to understand the immunopathology so that prevention, diagnosis and treatment can be improved.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1570-162X
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Bentham Science Publishers Ltd.
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-42
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:15279587-AIDS-Related Opportunistic Infections, pubmed-meshheading:15279587-Anti-HIV Agents, pubmed-meshheading:15279587-Antigens, CD30, pubmed-meshheading:15279587-Antiretroviral Therapy, Highly Active, pubmed-meshheading:15279587-Autoimmune Diseases, pubmed-meshheading:15279587-Biological Markers, pubmed-meshheading:15279587-Cytomegalovirus, pubmed-meshheading:15279587-Dipeptidyl Peptidase 4, pubmed-meshheading:15279587-Genetic Predisposition to Disease, pubmed-meshheading:15279587-HIV Infections, pubmed-meshheading:15279587-Hepacivirus, pubmed-meshheading:15279587-Herpesvirus 3, Human, pubmed-meshheading:15279587-Humans, pubmed-meshheading:15279587-Immunoglobulin G, pubmed-meshheading:15279587-Interleukin-6, pubmed-meshheading:15279587-Mycobacterium, pubmed-meshheading:15279587-Simplexvirus
pubmed:year
2004
pubmed:articleTitle
Immune restoration disease: a consequence of dysregulated immune responses after HAART.
pubmed:affiliation
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia. sfstone@cyllene.uwa.edu.au
pubmed:publicationType
Journal Article, Review