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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
31
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pubmed:dateCreated |
2004-8-4
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pubmed:abstractText |
The roles of the androgen receptor (AR) in female fertility and ovarian function remain largely unknown. Here we report on the generation of female mice lacking AR (AR(-/-)) and the resulting influences on the reproductive system. Female AR(-/-) mice appear normal but show longer estrous cycles and reduced fertility. The ovaries from sexually mature AR(-/-) females exhibited a marked reduction in the number of corpora lutea. After superovulation treatment, the AR(-/-) ovaries produced fewer oocytes and also showed fewer corpora lutea. During the periovulatory period, an intensive granulosa apoptosis event occurs in the AR(-/-) preovulatory follicles, concurrent with the down-regulation of p21 and progesterone receptor expression. Furthermore, the defective conformation of the cumulus cell-oocyte complex from the AR(-/-) females implies a lower fertilization capability of the AR(-/-) oocytes. In addition to insufficient progesterone production, the diminished endometrial growth in uteri in response to exogenous gonadotropins indicates that AR(-/-) females exhibit a luteal phase defect. Taken together, these data provide in vivo evidence showing that AR plays an important role in female reproduction.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-10076995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-10318905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-10411511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-10443703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-10782364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-10859235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-11016951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-11606461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-11751267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-11943742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-12077405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-12297526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-12370412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-12416998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-12611600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-12959984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-14676301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-15082523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-15107499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-1571482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-1577930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-3353726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-6105650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-6773744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-8404672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-8701090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-9603245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-9610467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-9658398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-9661631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-9713373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277682-976193
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11209-14
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15277682-Animals,
pubmed-meshheading:15277682-Apoptosis,
pubmed-meshheading:15277682-Female,
pubmed-meshheading:15277682-Gene Expression Regulation, Developmental,
pubmed-meshheading:15277682-In Situ Nick-End Labeling,
pubmed-meshheading:15277682-Infertility, Female,
pubmed-meshheading:15277682-Mice,
pubmed-meshheading:15277682-Mice, Mutant Strains,
pubmed-meshheading:15277682-Ovarian Follicle,
pubmed-meshheading:15277682-Phenotype,
pubmed-meshheading:15277682-Receptors, Androgen,
pubmed-meshheading:15277682-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15277682-Superovulation,
pubmed-meshheading:15277682-Uterus
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pubmed:year |
2004
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pubmed:articleTitle |
Subfertility and defective folliculogenesis in female mice lacking androgen receptor.
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pubmed:affiliation |
George Whipple Laboratory for Cancer Research, Departments of Pathology and Urology, University of Rochester, Rochester, NY 14642, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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