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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-8-3
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pubmed:abstractText |
Oxidized LDLs (oxLDLs) and matrix metalloproteinases (MMPs) are present in atherosclerotic lesions. OxLDLs activate various signaling pathways potentially involved in atherogenesis. OxLDLs induce smooth muscle cell (SMC) proliferation mediated by the activation of the sphingomyelin/ceramide pathway and tyrosine kinase receptors. MMPs are also able to induce SMC migration and proliferation in addition to extracellular matrix degradation. The present study was designed to investigate whether MMPs play a role in the mitogenic effect of oxLDLs.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ceramides,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lysophospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases...,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylalanine,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ro 28-2653,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingomyelin Phosphodiesterase,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingomyelins,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingosine,
http://linkedlifedata.com/resource/pubmed/chemical/Thiophenes,
http://linkedlifedata.com/resource/pubmed/chemical/batimastat,
http://linkedlifedata.com/resource/pubmed/chemical/oxidized low density lipoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/sphingosine 1-phosphate
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
571-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15277330-Animals,
pubmed-meshheading:15277330-Cell Division,
pubmed-meshheading:15277330-Cells, Cultured,
pubmed-meshheading:15277330-Ceramides,
pubmed-meshheading:15277330-DNA Replication,
pubmed-meshheading:15277330-Enzyme Activation,
pubmed-meshheading:15277330-Fibroblasts,
pubmed-meshheading:15277330-Humans,
pubmed-meshheading:15277330-Lipoproteins, LDL,
pubmed-meshheading:15277330-Lysophospholipids,
pubmed-meshheading:15277330-Matrix Metalloproteinase 2,
pubmed-meshheading:15277330-Matrix Metalloproteinases, Membrane-Associated,
pubmed-meshheading:15277330-Metalloendopeptidases,
pubmed-meshheading:15277330-Mice,
pubmed-meshheading:15277330-Mice, Knockout,
pubmed-meshheading:15277330-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:15277330-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:15277330-Muscle, Smooth, Vascular,
pubmed-meshheading:15277330-Myocytes, Smooth Muscle,
pubmed-meshheading:15277330-Phenylalanine,
pubmed-meshheading:15277330-Piperazines,
pubmed-meshheading:15277330-Protease Inhibitors,
pubmed-meshheading:15277330-Pyrimidines,
pubmed-meshheading:15277330-RNA, Small Interfering,
pubmed-meshheading:15277330-Rabbits,
pubmed-meshheading:15277330-Receptor, Epidermal Growth Factor,
pubmed-meshheading:15277330-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:15277330-Recombinant Proteins,
pubmed-meshheading:15277330-Signal Transduction,
pubmed-meshheading:15277330-Sphingomyelin Phosphodiesterase,
pubmed-meshheading:15277330-Sphingomyelins,
pubmed-meshheading:15277330-Sphingosine,
pubmed-meshheading:15277330-Thiophenes
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pubmed:year |
2004
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pubmed:articleTitle |
Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.
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pubmed:affiliation |
INSERM U-466, Department of Biochemistry, CHU Rangueil, Toulouse, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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