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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-7-27
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pubmed:abstractText |
The cardiac inwardly rectifying potassium current IK1 and its molecular correlates Kir2.1 and Kir2.2 play an important role in cardiac repolarisation and in the pathogenesis of hereditary long-QT syndrome (LQTS-7). Protein kinases A (PKA) and C (PKC) are key enzymes in adrenergic signal transduction, inducing arrhythmias in heart disease. This study investigated the regulation of Kir2.2 (KCNJ12) by PKA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:copyrightInfo |
Copryright 2004 European Society of Cardiology
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
520-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15276477-Animals,
pubmed-meshheading:15276477-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:15276477-Enzyme Activation,
pubmed-meshheading:15276477-Female,
pubmed-meshheading:15276477-Humans,
pubmed-meshheading:15276477-Ion Channel Gating,
pubmed-meshheading:15276477-Long QT Syndrome,
pubmed-meshheading:15276477-Male,
pubmed-meshheading:15276477-Myocardium,
pubmed-meshheading:15276477-Oocytes,
pubmed-meshheading:15276477-Patch-Clamp Techniques,
pubmed-meshheading:15276477-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:15276477-Protein Kinase C,
pubmed-meshheading:15276477-Xenopus
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pubmed:year |
2004
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pubmed:articleTitle |
Human cardiac inwardly rectifying current IKir2.2 is upregulated by activation of protein kinase A.
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pubmed:affiliation |
Department of Cardiology, Medical University Hospital Heidelberg, Bergheimerstrasse 58, D-69115, Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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