Source:http://linkedlifedata.com/resource/pubmed/id/15276180
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2004-7-27
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| pubmed:abstractText |
The activity of membrane-type 1 matrix metalloproteinase (MT1-MMP) is a double-edged sword--it is crucial for both physiological processes and disease progression. MT1-MMP modifies various cellular functions and it is, sthus, regulated precisely as a proteinase and as a membrane protein. Recent studies have further revealed that the function of MT1-MMP is modified and regulated by O-glycosylation, interaction with CD44, internalization and recycling. Such multidimensional mechanisms enable MT1-MMP to be regulated spatially and temporally, and are essential for its proper functioning on the cell surface.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0968-0004
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
285-9
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15276180-Antigens, CD44,
pubmed-meshheading:15276180-Cell Membrane,
pubmed-meshheading:15276180-Glycosylation,
pubmed-meshheading:15276180-Humans,
pubmed-meshheading:15276180-Matrix Metalloproteinases, Membrane-Associated,
pubmed-meshheading:15276180-Membrane Proteins,
pubmed-meshheading:15276180-Metalloendopeptidases
|
| pubmed:year |
2004
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| pubmed:articleTitle |
MT1-MMP: an enzyme with multidimensional regulation.
|
| pubmed:affiliation |
Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Imperial College London, Hammersmith, London W6 8LH, UK.
|
| pubmed:publicationType |
Journal Article
|