Source:http://linkedlifedata.com/resource/pubmed/id/15275430
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2004-7-27
|
| pubmed:abstractText |
The expression of cytolytic activity and production of interferon gamma (IFN-gamma) by CD8(+) T cells is thought to play a fundamental role in protection against infection by viruses and intracellular parasites. François Erard and Graham Le Gros have recently shown that CD8(+) T cells activated in the presence of interleukin 4 (IL-4) can switch development to a CD8(-)CD4(-)Th2-like phenotype that is not cytolytic and that does not produce IFN-gamma. Here they speculate on whether this IL-4-induced switch is used by the host to make a more-effective response against parasite invasion, or i f it is a host mechanism used by the parasite to evade protective CD8(+) T-cell responses.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0169-4758
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
313-5
|
| pubmed:year |
1994
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| pubmed:articleTitle |
Th2-like CD8 T cells: their role in protection against infectious diseases.
|
| pubmed:affiliation |
Pharmaceuticals Research Division, Ciba-Geigy Ltd, CH-4002 Basel, Switzerland.
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| pubmed:publicationType |
Journal Article
|