Source:http://linkedlifedata.com/resource/pubmed/id/15274359
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3a
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pubmed:dateCreated |
2004-7-27
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pubmed:abstractText |
There are several advantages to combinatorial chemoprevention strategies over monotherapeutic approaches. Both the HMG-CoA reductase inhibitor (HRI) lovastatin (LOV) and the selective apoptotic antineoplastic drug (SAAND) exisulind (EXS) have shown remarkable chemopreventive effects in previous studies, in cell lines and limited studies in rodents. Here, experiments were designed to assess the potential use of these two compounds in combinatorial chemoprevention therapy, using two bio-assays in which inhibition of the carcinogen-induced preneoplastic lesions, aberrant crypt foci (ACF), was used to quantitate efficacy.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1805-11
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pubmed:dateRevised |
2006-4-24
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pubmed:meshHeading |
pubmed-meshheading:15274359-Animals,
pubmed-meshheading:15274359-Anticarcinogenic Agents,
pubmed-meshheading:15274359-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15274359-Colonic Neoplasms,
pubmed-meshheading:15274359-Dose-Response Relationship, Drug,
pubmed-meshheading:15274359-Lovastatin,
pubmed-meshheading:15274359-Male,
pubmed-meshheading:15274359-Precancerous Conditions,
pubmed-meshheading:15274359-Random Allocation,
pubmed-meshheading:15274359-Rats,
pubmed-meshheading:15274359-Rats, Inbred F344,
pubmed-meshheading:15274359-Sulindac
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pubmed:articleTitle |
Combinatorial chemoprevention: efficacy of lovostatin and exisulind on the formation and progression of aberrant crypt foci.
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pubmed:affiliation |
Division of Basic Research and Department of Pathology, University of South Carolina School of Medicine, South Carolina Cancer Center, Columbia, SC 29203, USA.
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pubmed:publicationType |
Journal Article
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