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rdf:type |
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lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0026809,
umls-concept:C0034783,
umls-concept:C0079281,
umls-concept:C0234422,
umls-concept:C0332206,
umls-concept:C0441655,
umls-concept:C0599668,
umls-concept:C1157570,
umls-concept:C1280500
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pubmed:issue |
2
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pubmed:dateCreated |
2004-7-26
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pubmed:abstractText |
We studied the effects of blockade of nicotinic receptors in sympathetic and parasympathetic ganglia (hexamethonium), muscarinic receptors (atropine), and beta1-adrenoceptors (atenolol) on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis with Nomega-nitro-L-arginine in NMRI mice. Atropine reduced, while hexamethonium completely abolished the arrhythmogenic effect of endothelin-1 during nitric oxide synthase inhibition. Atenolol potentiated arrhythmogenic activity of Nomega-nitro-L-arginine, but endothelin-1 had no effect on the incidence of arrhythmias under these conditions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-4888
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-3
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15273750-Adrenergic Antagonists,
pubmed-meshheading:15273750-Animals,
pubmed-meshheading:15273750-Arrhythmias, Cardiac,
pubmed-meshheading:15273750-Atenolol,
pubmed-meshheading:15273750-Atropine,
pubmed-meshheading:15273750-Cholinergic Antagonists,
pubmed-meshheading:15273750-Endothelin-1,
pubmed-meshheading:15273750-Hexamethonium,
pubmed-meshheading:15273750-Male,
pubmed-meshheading:15273750-Mice,
pubmed-meshheading:15273750-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:15273750-Nitric Oxide
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pubmed:year |
2004
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pubmed:articleTitle |
Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis in awake mice.
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pubmed:affiliation |
Laboratory of Biological Assays, Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia. lobanov_al@pisem.net
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pubmed:publicationType |
Journal Article
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