Source:http://linkedlifedata.com/resource/pubmed/id/15273735
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
40
|
| pubmed:dateCreated |
2004-9-2
|
| pubmed:databankReference | |
| pubmed:abstractText |
We have determined the expression profiles of cdh7, and the related cdh20 during development. Both transcripts are found in the adult brain, but only cadherin-20 mRNA was detected during embryogenesis. In mouse embryos, cadherin-20 is synthesized by the forebrain, anterior neural ridge, developing visual system, primitive external granular layer of the cerebellum and a subset of neural crest cells likely to develop into melanoblasts. We found that the other embryonic tissues in which cadherin-20 was synthesized depended on genetic background. Melanoma cell lines contained transcripts for cadherin-7 but not for cadherin-20. The majority of the malignant melanoma cell lines produced N-cadherin (N-Cad) and/or cadherin-7 whereas melanocyte cell lines did not. The converse was observed for E-cadherin (E-Cad). Our data suggest that during development cadherin-20 is a key player in compartmentalization of the neural tube and establishment of neural circuitry. Finally, during oncogenesis, cadherin-7, N-cad and E-cad could be used as an efficient marker set for melanoma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0950-9232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6726-35
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15273735-Amino Acid Sequence,
pubmed-meshheading:15273735-Animals,
pubmed-meshheading:15273735-Base Sequence,
pubmed-meshheading:15273735-Brain,
pubmed-meshheading:15273735-Cadherins,
pubmed-meshheading:15273735-Cell Line, Tumor,
pubmed-meshheading:15273735-Cell Transformation, Neoplastic,
pubmed-meshheading:15273735-Cloning, Molecular,
pubmed-meshheading:15273735-Conserved Sequence,
pubmed-meshheading:15273735-Embryonic and Fetal Development,
pubmed-meshheading:15273735-Gene Expression Regulation, Developmental,
pubmed-meshheading:15273735-In Situ Hybridization,
pubmed-meshheading:15273735-Melanocytes,
pubmed-meshheading:15273735-Melanoma,
pubmed-meshheading:15273735-Mice,
pubmed-meshheading:15273735-Molecular Sequence Data,
pubmed-meshheading:15273735-Organ Specificity,
pubmed-meshheading:15273735-RNA, Messenger,
pubmed-meshheading:15273735-Sequence Alignment,
pubmed-meshheading:15273735-Sequence Homology, Amino Acid,
pubmed-meshheading:15273735-Transcription, Genetic
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation.
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| pubmed:affiliation |
Developmental Genetics of Melanocytes, UMR146 CNRS, Institut Curie, Bat. 110, 91405 Orsay Cedex, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|