Linked Life Data

15273715

Source:http://linkedlifedata.com/resource/pubmed/id/15273715

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
44
pubmed:dateCreated
2004-9-23
pubmed:abstractText
Papillary thyroid carcinoma (PTC) is associated with RET and NTRK1 rearrangements and BRAF mutations. A series of 60 PTCs collected in a single center from Italian patients were histologically re-examined and subclassified as well differentiated or tall cell variant. The sample collection was analysed for the presence of all the reported PTC-associated genetic alterations through DNA or cDNA amplification, followed by automated sequencing. The analysis of exons 11 and 15 of BRAF gene revealed the T1796A (V599E) mutation in 32% of cases, and this alteration is significantly associated with PTC tall cell variant. Oncogenic rearrangements of RET and NTRK1 receptors were found in 33 and 5% of cases, respectively. No Ras mutations were detected. Overall, genetic alterations were detected in two-thirds of samples, and in no single case more than one mutational event was found simultaneously. Gene expression profiling of a subset of 31 tumors performed using cDNA microarray chips showed no strong differences in global gene expression among the different cases. However, a supervised analysis of the obtained data identified a subset of genes differentially expressed in tumors carrying BRAF mutation or RTK rearrangement.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7436-40
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15273715-Adenocarcinoma, Papillary, pubmed-meshheading:15273715-Amino Acid Substitution, pubmed-meshheading:15273715-Gene Expression Profiling, pubmed-meshheading:15273715-Gene Rearrangement, pubmed-meshheading:15273715-Genetic Variation, pubmed-meshheading:15273715-Humans, pubmed-meshheading:15273715-Italy, pubmed-meshheading:15273715-Mutation, pubmed-meshheading:15273715-Mutation, Missense, pubmed-meshheading:15273715-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:15273715-Oncogene Proteins, pubmed-meshheading:15273715-Proto-Oncogene Proteins B-raf, pubmed-meshheading:15273715-Proto-Oncogene Proteins c-raf, pubmed-meshheading:15273715-Proto-Oncogene Proteins c-ret, pubmed-meshheading:15273715-Receptor, trkA, pubmed-meshheading:15273715-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:15273715-Thyroid Neoplasms
pubmed:year
2004
pubmed:articleTitle
Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer.
pubmed:affiliation
Department of Pathology, Experimental Molecular Pathology, Istituto Nazionale Tumori, Milan, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't