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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-7-26
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pubmed:abstractText |
The aetiology of the autoimmune thyroid diseases (AITDs), Graves' disease (GD) and Hashimoto's thyroiditis is largely unknown. However, genetic susceptibility is believed to play a major role. Two whole genome scans from Japan and from the USA identified a locus on chromosome 8q24 which showed evidence for linkage with AITD and HT. Recent studies have demonstrated an association between a Tg polymorphisms and AITD, suggesting that Tg is the susceptibility gene on 8q24.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0300-0664
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15272924-Alleles,
pubmed-meshheading:15272924-Case-Control Studies,
pubmed-meshheading:15272924-Chromosomes, Human, Pair 8,
pubmed-meshheading:15272924-Exons,
pubmed-meshheading:15272924-Female,
pubmed-meshheading:15272924-Gene Frequency,
pubmed-meshheading:15272924-Genetic Predisposition to Disease,
pubmed-meshheading:15272924-Genotype,
pubmed-meshheading:15272924-Humans,
pubmed-meshheading:15272924-Introns,
pubmed-meshheading:15272924-Japan,
pubmed-meshheading:15272924-Male,
pubmed-meshheading:15272924-Microsatellite Repeats,
pubmed-meshheading:15272924-Middle Aged,
pubmed-meshheading:15272924-Polymorphism, Single Nucleotide,
pubmed-meshheading:15272924-Thyroglobulin,
pubmed-meshheading:15272924-Thyroiditis, Autoimmune
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pubmed:year |
2004
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pubmed:articleTitle |
Association of a thyroglobulin gene polymorphism with Hashimoto's thyroiditis in the Japanese population.
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pubmed:affiliation |
Third Department of Internal Medicine, School of Pharmaceutical Sciences, Showa University, Shinagawa-ku, Tokyo, Japan. yshyban@aol.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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