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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-7-23
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pubmed:abstractText |
Monocytes are circulating precursors of the dendritic cell subset, professional antigen-presenting cells with a unique ability to initiate the innate and adaptive immune response. In this study, we have investigated the effects of wild-type Helicobacter pylori strains and their isogenic mutants with mutations in known bacterial virulence factors on monocytes and monocyte-derived dendritic cells. We show that H. pylori strains induce apoptosis of human monocytes by a mechanism that is dependent on the expression of a functional cag pathogenicity island. This effect requires an intact injection organelle for direct contact between monocytes and the bacteria but also requires a still-unidentified effector that is different from VacA or CagA. The exposure of in vitro-generated monocyte-derived dendritic cells to H. pylori stimulates the release of inflammatory cytokines by a similar mechanism. Of note is that dendritic cells are resistant to H. pylori-induced apoptosis. These phenomena may play a critical role in the evasion of the immune response by H. pylori, contributing to the persistence of the infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-10655986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-11173032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-11207544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-11238562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-11743164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-11886563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-11902583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-11929545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-11971019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-11988519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-12419219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-12615708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-12775840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-12819109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-1910679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-7806390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-8144644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-8145033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-8825091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-8962108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-9521319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-9754563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15271906-9826379
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4480-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15271906-Antigens, Bacterial,
pubmed-meshheading:15271906-Apoptosis,
pubmed-meshheading:15271906-Bacterial Proteins,
pubmed-meshheading:15271906-Cell Differentiation,
pubmed-meshheading:15271906-Cytokines,
pubmed-meshheading:15271906-Dendritic Cells,
pubmed-meshheading:15271906-Helicobacter pylori,
pubmed-meshheading:15271906-Humans,
pubmed-meshheading:15271906-Monocytes,
pubmed-meshheading:15271906-Virulence
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pubmed:year |
2004
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pubmed:articleTitle |
Helicobacter pylori induces apoptosis of human monocytes but not monocyte-derived dendritic cells: role of the cag pathogenicity island.
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pubmed:affiliation |
Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, Università di Napoli Federico II, Naples, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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