Linked Life Data

15271801

Source:http://linkedlifedata.com/resource/pubmed/id/15271801

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2004-11-4
pubmed:abstractText
The immune system contains natural regulatory T cells that control the magnitude of the immune response during physiologic and pathologic conditions. Although this suppressive function was historically attributed to CD8 T cells, most recent reports have focused on natural regulatory CD4 T cells. In the present study, we describe a new subset of natural CD8 regulatory T cells in normal healthy animals. This subset expresses low levels of CD45RC at its surface (CD45RC(low)); produces mainly interleukin-4 (IL-4), IL-10, and IL-13 cytokines upon in vitro stimulation; expresses Foxp3 and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4); and is not cytotoxic against allogeneic targets. This subset suppresses the proliferation and differentiation of autologous CD4 T cells into type-1 cytokines producing T cells after stimulation with allogeneic accessory cells. We also provide evidence that this regulatory subset mediates its suppression by cell-to-cell contact and not through secretion of suppressive cytokines. Finally, the regulatory activity of CD8 CD45RC(low) cells is also demonstrated in vivo in a rat model of CD4-dependent graft-versus-host disease. Collectively, these data demonstrate for the first time that freshly isolated rat CD8 CD45RC(low) T cells contain T cells with regulatory properties, a result that enlarges the general picture of T-cell-mediated regulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3294-301
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15271801-Acute Disease, pubmed-meshheading:15271801-Adoptive Transfer, pubmed-meshheading:15271801-Animals, pubmed-meshheading:15271801-Antigens, CD, pubmed-meshheading:15271801-Antigens, CD45, pubmed-meshheading:15271801-Antigens, Differentiation, pubmed-meshheading:15271801-Biological Markers, pubmed-meshheading:15271801-CD8-Positive T-Lymphocytes, pubmed-meshheading:15271801-CTLA-4 Antigen, pubmed-meshheading:15271801-Cell Communication, pubmed-meshheading:15271801-Cell Differentiation, pubmed-meshheading:15271801-Cell Division, pubmed-meshheading:15271801-Cytokines, pubmed-meshheading:15271801-DNA-Binding Proteins, pubmed-meshheading:15271801-Graft vs Host Disease, pubmed-meshheading:15271801-Male, pubmed-meshheading:15271801-Protein Tyrosine Phosphatase, Non-Receptor Type 1, pubmed-meshheading:15271801-RNA, Messenger, pubmed-meshheading:15271801-Rats, pubmed-meshheading:15271801-Rats, Inbred BN, pubmed-meshheading:15271801-Rats, Inbred Lew, pubmed-meshheading:15271801-T-Lymphocyte Subsets, pubmed-meshheading:15271801-Transplantation, Homologous
pubmed:year
2004
pubmed:articleTitle
Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation.
pubmed:affiliation
Institut National de la Santé et de la Recherche Médicale U563, Hôpital Purpan and Université Paul Sabatier, Toulouse, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't