Linked Life Data

15271259

Source:http://linkedlifedata.com/resource/pubmed/id/15271259

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-7-23
pubmed:abstractText
The hypothalamic suprachiasmatic nucleus (SCN) has a pivotal role in the mammalian circadian clock. SCN neurons generate circadian rhythms in action potential firing frequencies and neurotransmitter release, and the core oscillation is thought to be driven by "clock gene" transcription-translation feedback loops. Cytosolic Ca2+ mobilization followed by stimulation of various receptors has been shown to reset the gene transcription cycles in SCN neurons, whereas contribution of steady-state cytosolic Ca2+ levels to the rhythm generation is unclear. Recently, circadian rhythms in cytosolic Ca2+ levels have been demonstrated in cultured SCN neurons. The circadian Ca2+ rhythms are driven by the release of Ca2+ from ryanodine-sensitive internal stores and resistant to the blockade of action potentials. These results raise the possibility that gene translation/transcription loops may interact with autonomous Ca2+ oscillations in the production of circadian rhythms in SCN neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1073-8584
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-24
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Calcium dynamics and circadian rhythms in suprachiasmatic nucleus neurons.
pubmed:affiliation
Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka, Japan. msikeda@obi.or.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't