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pubmed-article:1526872rdf:typepubmed:Citationlld:pubmed
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pubmed-article:1526872pubmed:dateCreated1992-10-22lld:pubmed
pubmed-article:1526872pubmed:abstractTextThree-dimensional dose distributions have been calculated for LS174T human colon cancer xenografts in athymic nude mice treated with 131I-labeled 17-1A monoclonal antibody. Autoradiographs were made for fifteen to twenty 32-micron-thick representative serial sections of tumors removed 1 and 4 days postinjection. Film density readings were converted to activity density and entered into a radiotherapy treatment planning system. Three-dimensional dose distributions were obtained by summing the dose contributions due to each voxel of uniform activity. Isodoserate distributions and dose-rate-volume histograms for representative tumors at 1 and 4 days following 131I-labeled 17-1A injection showed a progressive change from a predominantly surface deposition (day 1) to a more volumetric deposition (day 4). Average tumor doses calculated using the assumptions of uniform source distribution and local dose deposition resulted in a poor estimation of the cumulative dose because of the significant time-dependent dose-rate nonuniformities.lld:pubmed
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pubmed-article:1526872pubmed:statusMEDLINElld:pubmed
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pubmed-article:1526872pubmed:authorpubmed-author:BuchsbaumD...lld:pubmed
pubmed-article:1526872pubmed:authorpubmed-author:Ten HakenR...lld:pubmed
pubmed-article:1526872pubmed:authorpubmed-author:RobersonP LPLlld:pubmed
pubmed-article:1526872pubmed:authorpubmed-author:HeidornD BDBlld:pubmed
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pubmed-article:1526872pubmed:volume24lld:pubmed
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pubmed-article:1526872pubmed:pagination329-34lld:pubmed
pubmed-article:1526872pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:1526872pubmed:year1992lld:pubmed
pubmed-article:1526872pubmed:articleTitleThree-dimensional tumor dosimetry for radioimmunotherapy using serial autoradiography.lld:pubmed
pubmed-article:1526872pubmed:affiliationDepartment of Radiation Oncology, University of Michigan, Ann Arbor.lld:pubmed
pubmed-article:1526872pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1526872pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed