Linked Life Data

1526872

Source:http://linkedlifedata.com/resource/pubmed/id/1526872

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-10-22
pubmed:abstractText
Three-dimensional dose distributions have been calculated for LS174T human colon cancer xenografts in athymic nude mice treated with 131I-labeled 17-1A monoclonal antibody. Autoradiographs were made for fifteen to twenty 32-micron-thick representative serial sections of tumors removed 1 and 4 days postinjection. Film density readings were converted to activity density and entered into a radiotherapy treatment planning system. Three-dimensional dose distributions were obtained by summing the dose contributions due to each voxel of uniform activity. Isodoserate distributions and dose-rate-volume histograms for representative tumors at 1 and 4 days following 131I-labeled 17-1A injection showed a progressive change from a predominantly surface deposition (day 1) to a more volumetric deposition (day 4). Average tumor doses calculated using the assumptions of uniform source distribution and local dose deposition resulted in a poor estimation of the cumulative dose because of the significant time-dependent dose-rate nonuniformities.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0360-3016
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-34
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Three-dimensional tumor dosimetry for radioimmunotherapy using serial autoradiography.
pubmed:affiliation
Department of Radiation Oncology, University of Michigan, Ann Arbor.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.