Linked Life Data

15268681

Source:http://linkedlifedata.com/resource/pubmed/id/15268681

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2004-7-22
pubmed:abstractText
Development of a viable blood substitute began by focusing on recreating the oxygen-carrying capacity of blood, leading to the recognition that haemoglobin (Hb) is presently unequalled for this function. However, as human Hb is the only realistic source of this protein, the production of a blood substitute that solves transfusional blood availability problems and shortages must introduce a multiplying factor between supply of natural blood and blood substitute, while maintaining equivalency of function/efficacy. In other words, a unit of blood should produce several units of equivalent blood substitute. This expansion is now possible because of new understanding of how blood delivers oxygen in the microcirculation and the consequences of reducing oxygen-carrying capacity in haemorrhage. This information is used to provide improved resuscitation capacity and maintenance of tissue metabolism by tailoring the properties of a blood substitute to the task of maintaining microvascular function, rather than oxygen delivery capacity. Resuscitation in an organism that is haemorrhaging requires maintenance perfusion, a process directly linked to the maintenance of adequate levels of shear stress on the endothelium, induced by either increased blood/plasma viscosity or increased blood flow velocity in the microcirculation. This process must also be intimately coupled with the requirement that no portion of the tissue is anoxic. This disparate set of requirements can be satisfied with high viscosity Hb solutions that have high affinity for oxygen, a combination of properties that causes the microcirculation to remain functional, and a requirement that supersedes restoration of oxygen-carrying capacity in the treatment of haemorrhage.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1744-7682
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1147-57
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:15268681-Animals, pubmed-meshheading:15268681-Anoxia, pubmed-meshheading:15268681-Blood Flow Velocity, pubmed-meshheading:15268681-Blood Substitutes, pubmed-meshheading:15268681-Blood Viscosity, pubmed-meshheading:15268681-Capillaries, pubmed-meshheading:15268681-Cattle, pubmed-meshheading:15268681-Drug Carriers, pubmed-meshheading:15268681-Drug Compounding, pubmed-meshheading:15268681-Exchange Transfusion, Whole Blood, pubmed-meshheading:15268681-Hemoglobins, pubmed-meshheading:15268681-Hemorrhage, pubmed-meshheading:15268681-Humans, pubmed-meshheading:15268681-Hypertension, pubmed-meshheading:15268681-Liposomes, pubmed-meshheading:15268681-Microcirculation, pubmed-meshheading:15268681-Oxidative Stress, pubmed-meshheading:15268681-Oxygen, pubmed-meshheading:15268681-Partial Pressure, pubmed-meshheading:15268681-Reactive Oxygen Species, pubmed-meshheading:15268681-Shock, pubmed-meshheading:15268681-Vasoconstriction
pubmed:year
2004
pubmed:articleTitle
Oxygen-carrying blood substitutes: a microvascular perspective.
pubmed:affiliation
Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA. agtsai@ucsd.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review