Linked Life Data

1526732

Source:http://linkedlifedata.com/resource/pubmed/id/1526732

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1992-10-22
pubmed:abstractText
Human retinal pigment epithelial (RPE) cell monolayers were used in an in vitro wound-healing experiment. Wound closure were studied over time in the presence of various concentrations of all-trans retinol (vitamin A). It was found that 5-20 micrograms/ml (17.5-70 mumol/l) of vitamin A significantly inhibited wound closure by inhibiting cell migration and proliferation. In a collagen gel-contraction model, similar doses of vitamin A partially inhibited cell contractility. Cellular morphology, as assessed by phase-contrast microscopy, changed from a regular polygonal shape to an elongated stellate shape. Indirect immunofluorescence patterns of fibronectin, actin, tubulin, and vimentin were altered after exposure to vitamin A. All these effects were reversible after removal of the drug from the medium. Modulation of RPE growth and cell-mediated contraction may be useful in the treatment of ocular proliferative diseases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2830-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Effects of vitamin A on retinal pigment epithelial cells in vitro.
pubmed:affiliation
Eye Research Institute, Oakland University, Rochester, Michigan.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't