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pubmed-article:15267231pubmed:abstractTextGamma-secretase is the second of two proteolytic enzymes responsible for the release of the amyloid beta-peptide implicated in the etiology of Alzheimer's disease. Here, we used solid-phase synthesis to generate a new series of helical peptides as gamma-secretase inhibitors, one of which, 11, showed an IC(50) of 140 pM in a cell-free enzyme assay.lld:pubmed
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pubmed-article:15267231pubmed:articleTitleDiscovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.lld:pubmed
pubmed-article:15267231pubmed:affiliationCenter for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.lld:pubmed
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pubmed-article:15267231pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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