Source:http://linkedlifedata.com/resource/pubmed/id/15267231
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
16
|
| pubmed:dateCreated |
2004-7-22
|
| pubmed:abstractText |
Gamma-secretase is the second of two proteolytic enzymes responsible for the release of the amyloid beta-peptide implicated in the etiology of Alzheimer's disease. Here, we used solid-phase synthesis to generate a new series of helical peptides as gamma-secretase inhibitors, one of which, 11, showed an IC(50) of 140 pM in a cell-free enzyme assay.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
29
|
| pubmed:volume |
47
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3931-3
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15267231-Amyloid Precursor Protein Secretases,
pubmed-meshheading:15267231-Circular Dichroism,
pubmed-meshheading:15267231-Endopeptidases,
pubmed-meshheading:15267231-Peptides,
pubmed-meshheading:15267231-Protease Inhibitors,
pubmed-meshheading:15267231-Protein Structure, Secondary,
pubmed-meshheading:15267231-Stereoisomerism,
pubmed-meshheading:15267231-Structure-Activity Relationship
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
|
| pubmed:affiliation |
Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|