|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2004-7-21
|
|
pubmed:abstractText |
FTY720 is a prodrug for FTY-phosphate, an agonist at four of the five known receptors for sphingosine-1-phosphate (S1P). We show that administration of either FTY720 or FTY-P to SJL mice with established relapsing-remitting experimental autoimmune encephalitis (EAE) results in a rapid and sustained improvement in their clinical status, and a reversal of changes in expression of mRNAs encoding some myelin proteins and inflammatory mediators. EAE produced by adoptively transferring lymph node cells from immunized mice to naïve hosts is similarly ameliorated by FTY-P. Treatment with FTY-P is accompanied by a dose-responsive peripheral lymphopoenia.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Mitoxantrone,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Proteolipid Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Propylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lysophospholipid,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingosine,
http://linkedlifedata.com/resource/pubmed/chemical/fingolimod,
http://linkedlifedata.com/resource/pubmed/chemical/myelin proteolipid protein (139-151)
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0165-5728
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
153
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
108-21
|
|
pubmed:dateRevised |
2011-8-26
|
|
pubmed:meshHeading |
pubmed-meshheading:15265669-Animals,
pubmed-meshheading:15265669-Antineoplastic Agents,
pubmed-meshheading:15265669-Disease Models, Animal,
pubmed-meshheading:15265669-Dose-Response Relationship, Drug,
pubmed-meshheading:15265669-Drug Interactions,
pubmed-meshheading:15265669-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:15265669-Female,
pubmed-meshheading:15265669-Gene Expression Regulation,
pubmed-meshheading:15265669-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:15265669-Immunosuppressive Agents,
pubmed-meshheading:15265669-Interferon-gamma,
pubmed-meshheading:15265669-Lymphocytes,
pubmed-meshheading:15265669-Lymphopenia,
pubmed-meshheading:15265669-Mice,
pubmed-meshheading:15265669-Mice, Inbred Strains,
pubmed-meshheading:15265669-Mitoxantrone,
pubmed-meshheading:15265669-Molecular Sequence Data,
pubmed-meshheading:15265669-Myelin Proteins,
pubmed-meshheading:15265669-Myelin Proteolipid Protein,
pubmed-meshheading:15265669-Nitric Oxide Synthase,
pubmed-meshheading:15265669-Nitric Oxide Synthase Type II,
pubmed-meshheading:15265669-Peptide Fragments,
pubmed-meshheading:15265669-Propylene Glycols,
pubmed-meshheading:15265669-RNA, Messenger,
pubmed-meshheading:15265669-Receptors, G-Protein-Coupled,
pubmed-meshheading:15265669-Receptors, Lysophospholipid,
pubmed-meshheading:15265669-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15265669-Sphingosine,
pubmed-meshheading:15265669-Time Factors
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.
|
|
pubmed:affiliation |
Molecular Neuroscience Laboratory, Merck Research Laboratories, 3535 General Atomics Court, San Diego, CA 92121, USA. xhua@san.rr.com
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
