Linked Life Data

15265651

Source:http://linkedlifedata.com/resource/pubmed/id/15265651

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-7-21
pubmed:abstractText
The central serotonin (5-HT) system is important in regulating behaviors associated with anxiety and depression. While a fair amount is known about the role of 5-HT1 and 5-HT2 receptor subtypes in regulating these behaviors, much less is known about the involvement of the 5-HT3 receptor, especially with regards to its role in sex differences in behavior. Our goal in the present studies was to examine whether deletion of the 5-HT3 receptor produces different effects in adult male and female mice on performance in three behavioral tests. We examined behavior of male and female mice lacking the 5-HT3 receptor (knock-out or KO) and their wild-type (WT) littermates in the Porsolt forced swim test because of its importance in reliably detecting anti-depressant efficacy. In addition, we examined behavior in the defensive withdrawal test and repeated exposure to an open field because behavior in these two tests provides measures of anxiety. In the Porsolt swim test, sex differences were eliminated by deletion of the 5-HT3 receptor while deletion had no effect in the habituation of locomotor activity to repeated exposure to an open field. In the defensive withdrawal test, deletion of the 5-HT3 receptor had more complex effects though these effects tended to be in the opposite direction in males and females. Together these results suggest that the 5-HT3 receptor regulates behavior-related to depression and anxiety differently in males and females. Whether these effects are due to the interaction of 5-HT3 receptor with gonadal hormones requires further examination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0166-4328
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
153
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
527-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Deletion of the 5-HT3 receptor differentially affects behavior of males and females in the Porsolt forced swim and defensive withdrawal tests.
pubmed:affiliation
Department of Psychology, University of Michigan, 525 East University, Box 1109, Ann Arbor, MI 48109-1109, USA. bhatnags@umich.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't