Source:http://linkedlifedata.com/resource/pubmed/id/15265493
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
16
|
| pubmed:dateCreated |
2004-7-21
|
| pubmed:abstractText |
This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC(50) 2.6+/-0.9microM at 72h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0968-0896
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4423-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15265493-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:15265493-Apoptosis,
pubmed-meshheading:15265493-Dracaena,
pubmed-meshheading:15265493-HL-60 Cells,
pubmed-meshheading:15265493-Humans,
pubmed-meshheading:15265493-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:15265493-Saponins,
pubmed-meshheading:15265493-Steroids
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco.
|
| pubmed:affiliation |
Instituto de Productos Naturales y Agrobiología-CSIC, Instituto Universitario de Bio-Orgánica Antonio González, La Laguna, Tenerife, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|