Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
1992-10-22
|
| pubmed:abstractText |
Enterobacter aerogenes mutants with high-level resistance to imipenem were studied. They were derived from strains characterized by stable over-production of a class-I beta-lactamase. This enzyme (pI = 8.2) exhibited high affinity toward imipenem and hydrolysed the drug slowly. Imipenem-resistant mutants lacked a major 43-kDa outer membrane protein and displayed decreased permeability to cephaloridine. Introduction of a plasmid coding for the regulatory ampD gene abolished beta-lactamase production and rendered the mutants susceptible to imipenem.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0378-1097
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
195-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1526451-Cell Membrane Permeability,
pubmed-meshheading:1526451-Cephaloridine,
pubmed-meshheading:1526451-Cephalosporinase,
pubmed-meshheading:1526451-Drug Resistance, Microbial,
pubmed-meshheading:1526451-Enterobacter,
pubmed-meshheading:1526451-Imipenem,
pubmed-meshheading:1526451-Kinetics
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability.
|
| pubmed:affiliation |
Department of Bacteriology, Hellenic Pasteur Institute, Athens University, Greece.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|