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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-7-20
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pubmed:abstractText |
T cell antigen recognition involves the formation of a structured interface between antigen-presenting and T cells that facilitates the specific transmission of activating and desensitizing stimuli. The molecular machinery that organizes the signaling molecules and controls their disposition in response to activation remains poorly understood. We show here that in T cells Discs large (Dlg1), a PDZ domain-containing protein, is recruited upon activation to cortical actin and forms complexes with early participants in T cell activation. Transient overexpression of Dlg1 attenuates basal and Vav1-induced NFAT reporter activation. Reduction of Dlg1 expression by RNA interference enhances both CD3- and superantigen-mediated NFAT activation. Attenuation of antigen receptor signaling appears to be a complex, highly orchestrated event that involves the mutual segregation of important elements of the early signaling complex.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-10517864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-10629225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-10881170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-10939335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-11290340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-11728334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-11859198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-11910072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-11983154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-14562058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-14586424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-15095012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-15122200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-7623828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-7891172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-7937897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-8922391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-8974395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-9341123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-9683631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-9738502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15263016-9765270
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/DLG1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dlgh1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Dlgh1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NFATC Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Superantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9525
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pubmed:author |
pubmed-author:AndreNikoN,
pubmed-author:IshiguroKazuhiroK,
pubmed-author:Lopez-IlasacaMarcoM,
pubmed-author:MorrisDavid GDG,
pubmed-author:OrtizJ BernabeJB,
pubmed-author:RabizadehShahroozS,
pubmed-author:SeedBrianB,
pubmed-author:ShawAlbert CAC,
pubmed-author:SwatWojciechW,
pubmed-author:WachtelHeatherH,
pubmed-author:XavierRamnikR
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pubmed:copyrightInfo |
Copyright The Rockerfeller University Press
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
166
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15263016-Actins,
pubmed-meshheading:15263016-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:15263016-Animals,
pubmed-meshheading:15263016-Antigens, CD3,
pubmed-meshheading:15263016-DNA-Binding Proteins,
pubmed-meshheading:15263016-Guanylate Kinase,
pubmed-meshheading:15263016-Humans,
pubmed-meshheading:15263016-Jurkat Cells,
pubmed-meshheading:15263016-Lymphocyte Activation,
pubmed-meshheading:15263016-Membrane Proteins,
pubmed-meshheading:15263016-Mice,
pubmed-meshheading:15263016-Mice, Transgenic,
pubmed-meshheading:15263016-NFATC Transcription Factors,
pubmed-meshheading:15263016-Nuclear Proteins,
pubmed-meshheading:15263016-Protein Transport,
pubmed-meshheading:15263016-Proteins,
pubmed-meshheading:15263016-Rats,
pubmed-meshheading:15263016-Signal Transduction,
pubmed-meshheading:15263016-Superantigens,
pubmed-meshheading:15263016-T-Lymphocytes,
pubmed-meshheading:15263016-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Discs large (Dlg1) complexes in lymphocyte activation.
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pubmed:affiliation |
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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