Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1992-10-22
|
pubmed:abstractText |
Growth hormone (GH) increases plasma T3 and decreases plasma T4 in 18-day old chicken embryos, in newly hatched chicks and in adult chickens within 2 h after injection. The in vivo increase in T3 can be linked to an increased in vitro T3 recovery from liver homogenates incubated with T4. Specific type I and type III deiodinase tests (5'D-I and 5D-III), however, show that GH has no effect at all on the amount of hepatic type I enzyme (catalyzing T4 deiodination to T3) but acutely decreases the amount of type III enzyme (catalyzing T3 deiodination). This suggests that the GH-induced increase in plasma T3 is not due to an increased T3 production, but is the result of a decreased T3 breakdown. The lack of a stimulatory effect of GH injection in 3-day-old fed chicks might be the combined result of a low hepatic type III enzyme level and a low GH receptor availability at that stage.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Iodide Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroxine,
http://linkedlifedata.com/resource/pubmed/chemical/Triiodothyronine
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0014-5793
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
21
|
pubmed:volume |
310
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
5-8
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1526283-Animals,
pubmed-meshheading:1526283-Chick Embryo,
pubmed-meshheading:1526283-Chickens,
pubmed-meshheading:1526283-Growth Hormone,
pubmed-meshheading:1526283-Iodide Peroxidase,
pubmed-meshheading:1526283-Liver,
pubmed-meshheading:1526283-Radioimmunoassay,
pubmed-meshheading:1526283-Receptors, Somatotropin,
pubmed-meshheading:1526283-Thyroxine,
pubmed-meshheading:1526283-Triiodothyronine
|
pubmed:year |
1992
|
pubmed:articleTitle |
Growth hormone acutely decreases type III iodothyronine deiodinase in chicken liver.
|
pubmed:affiliation |
Laboratory of Comparative Endocrinology, K.U. Leuven, Belgium.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|