Linked Life Data

15261278

Source:http://linkedlifedata.com/resource/pubmed/id/15261278

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2004-7-20
pubmed:abstractText
To newly synthesize a selective opioid receptor antagonist, 17-(cyclopropylmethyl)-4,5 alpha-epoxy-6 beta,21-epoxymethano-3-hydroxy-6,14-endoethenomorphinan-7 alpha-(N-phenethyl)carboxamide was first designed from an opioid receptor agonist TAN-821 on the basis of the accessory site concept. The designed compound antagonized the agonistic effects induced by an opioid receptor agonist beta-endorphin on the rat vas deference test. Moreover, the designed compound blocked the antinociception induced by beta-endorphin given intracerebroventricularly.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4241-3
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Rational drug design and synthesis of a selective opioid receptor antagonist on the basis of the accessory site concept.
pubmed:affiliation
Pharmaceutical Research Laboratories, Toray Industries, Inc., 1111, Tebiro, Kamakura Kanagawa 248-8555, Japan. hideaki_fujii@nts.toray.co.jp
pubmed:publicationType
Journal Article