Source:http://linkedlifedata.com/resource/pubmed/id/15261164
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
2004-7-20
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pubmed:abstractText |
The molecular basis of the toxic properties of phenoxy herbicides in humans and animals has been insufficiently studied. In this study, damage parameters [levels of reduced glutathione (GSH) and total glutathione; activity of glutathione reductase (GR); activities of catalase (CAT) and superoxide dismutase (SOD); levels of adenine nucleotides and adenine energy charge (AEC)] were measured in human erythrocytes exposed in vitro to 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and its metabolite 2,4,5-trichlorophenol (2,4,5-TCP). Both 2,4,5-T and 2,4,5-TCP decreased the level of reduced glutathione (GSH) in erythrocytes in comparison to the control, but did not significantly change the total glutathione (2GSH + GSSG). This suggests that GSH concentration decreases concomitantly with an increase in oxidized glutathione (GSSG). 2,4,5-TCP at 100 ppm significantly decreased catalase and SOD activities. 2,4,5-T and 2,4,5-TCP did not significantly change the activity of glutathione reductase. 2,4,5-TCP decreased the level of ATP and increased the content of ADP and AMP, indicating a fall in AEC. 2,4,5-T and 2,4,5-TCP significantly changed the erythrocyte morphology. All these data are evidence of oxidative stress in erythrocytes incubated with 2,4,5-T and 2,4,5-TCP; the stress appears to be more intense in the case of 2,4,5-TCP.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,4,5-Trichlorophenoxyacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/2,4,5-trichlorophenol,
http://linkedlifedata.com/resource/pubmed/chemical/Catalase,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorophenols,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Herbicides,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase
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pubmed:status |
MEDLINE
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pubmed:issn |
1065-6995
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
557-63
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pubmed:meshHeading |
pubmed-meshheading:15261164-2,4,5-Trichlorophenoxyacetic Acid,
pubmed-meshheading:15261164-Animals,
pubmed-meshheading:15261164-Catalase,
pubmed-meshheading:15261164-Child,
pubmed-meshheading:15261164-Chlorophenols,
pubmed-meshheading:15261164-Erythrocytes,
pubmed-meshheading:15261164-Glutathione,
pubmed-meshheading:15261164-Herbicides,
pubmed-meshheading:15261164-Humans,
pubmed-meshheading:15261164-Molecular Structure,
pubmed-meshheading:15261164-Oxidation-Reduction,
pubmed-meshheading:15261164-Superoxide Dismutase
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pubmed:year |
2004
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pubmed:articleTitle |
2,4,5-T and 2,4,5-TCP induce oxidative damage in human erythrocytes: the role of glutathione.
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pubmed:affiliation |
Department of Biophysics of Environmental Pollution, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland. bukow@biol.uni.lodz.pl
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pubmed:publicationType |
Journal Article
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