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pubmed-article:15258717pubmed:abstractTextClozapine is a unique antipsychotic, with efficacy against positive symptoms in treatment-resistant schizophrenic patients, and the ability to improve cognition and treat the negative symptoms characteristic of this disease. Despite its unique clinical actions, no specific molecular mechanism responsible for these actions has yet been described.lld:pubmed
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pubmed-article:15258717pubmed:articleTitleThe role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine.lld:pubmed
pubmed-article:15258717pubmed:affiliationACADIA Pharmaceuticals, Inc., 3911 Sorrento Valley Boulevard, San Diego, CA, USA. dweiner@acadia-pharm.comlld:pubmed
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