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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2004-12-3
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pubmed:abstractText |
Clozapine is a unique antipsychotic, with efficacy against positive symptoms in treatment-resistant schizophrenic patients, and the ability to improve cognition and treat the negative symptoms characteristic of this disease. Despite its unique clinical actions, no specific molecular mechanism responsible for these actions has yet been described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0033-3158
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pubmed:author |
pubmed-author:BrannM RMR,
pubmed-author:BursteinE SES,
pubmed-author:DavisR ERE,
pubmed-author:DonohueE MEM,
pubmed-author:HacksellUU,
pubmed-author:HarveyS CSC,
pubmed-author:JayathilakeKK,
pubmed-author:LamehJJ,
pubmed-author:LeaII,
pubmed-author:LeveyA IAI,
pubmed-author:MeltzerH YHY,
pubmed-author:MohellNN,
pubmed-author:NasuSS,
pubmed-author:OlssonRR,
pubmed-author:SmithT TTT,
pubmed-author:SpaldingT ATA,
pubmed-author:VanoverK EKE,
pubmed-author:VeinbergsII,
pubmed-author:WeinerD MDM
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pubmed:issnType |
Print
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
207-16
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:15258717-Animals,
pubmed-meshheading:15258717-CHO Cells,
pubmed-meshheading:15258717-Clozapine,
pubmed-meshheading:15258717-Cricetinae,
pubmed-meshheading:15258717-Dose-Response Relationship, Drug,
pubmed-meshheading:15258717-Hippocampus,
pubmed-meshheading:15258717-Humans,
pubmed-meshheading:15258717-Mice,
pubmed-meshheading:15258717-Mice, Inbred C57BL,
pubmed-meshheading:15258717-Muscarinic Agonists,
pubmed-meshheading:15258717-NIH 3T3 Cells,
pubmed-meshheading:15258717-Receptor, Muscarinic M1
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pubmed:year |
2004
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pubmed:articleTitle |
The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine.
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pubmed:affiliation |
ACADIA Pharmaceuticals, Inc., 3911 Sorrento Valley Boulevard, San Diego, CA, USA. dweiner@acadia-pharm.com
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pubmed:publicationType |
Journal Article
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