| pubmed-article:15258591 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15258591 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15258591 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:15258591 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:15258591 | lifeskim:mentions | umls-concept:C0292687 | lld:lifeskim |
| pubmed-article:15258591 | lifeskim:mentions | umls-concept:C1428958 | lld:lifeskim |
| pubmed-article:15258591 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15258591 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15258591 | pubmed:dateCreated | 2004-8-10 | lld:pubmed |
| pubmed-article:15258591 | pubmed:abstractText | Repulsive guidance molecule (RGM) is an axon guidance protein that repels retinal axons upon activation of the neogenin receptor. To understand the functions of RGM-neogenin complexes in vivo, we used gene transfer technology to perturb their expression in the developing neural tube of chick embryos. Surprisingly, neogenin over-expression or RGM down-expression in the neural tube induces apoptosis. Neogenin pro-apoptotic activity in immortalized neuronal cells and in the neural tube is associated with the cleavage of its cytoplasmic domain by caspases. Thus neogenin is a dependence receptor inducing cell death in the absence of RGM, whereas the presence of RGM inhibits this effect. | lld:pubmed |
| pubmed-article:15258591 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15258591 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15258591 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15258591 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15258591 | pubmed:issn | 1465-7392 | lld:pubmed |
| pubmed-article:15258591 | pubmed:author | pubmed-author:Tauszig-Delam... | lld:pubmed |
| pubmed-article:15258591 | pubmed:author | pubmed-author:ChédotalAlain... | lld:pubmed |
| pubmed-article:15258591 | pubmed:author | pubmed-author:StrittmatterS... | lld:pubmed |
| pubmed-article:15258591 | pubmed:author | pubmed-author:MehlenPatrick... | lld:pubmed |
| pubmed-article:15258591 | pubmed:author | pubmed-author:MonnierPhilip... | lld:pubmed |
| pubmed-article:15258591 | pubmed:author | pubmed-author:MuellerBernha... | lld:pubmed |
| pubmed-article:15258591 | pubmed:author | pubmed-author:MatsunagaEiji... | lld:pubmed |
| pubmed-article:15258591 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15258591 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:15258591 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15258591 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15258591 | pubmed:pagination | 749-55 | lld:pubmed |
| pubmed-article:15258591 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15258591 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15258591 | pubmed:articleTitle | RGM and its receptor neogenin regulate neuronal survival. | lld:pubmed |
| pubmed-article:15258591 | pubmed:affiliation | UMR CNRS 7102, Université Paris 6, 9 Quai Saint Bernard, 75005 Paris, France. | lld:pubmed |
| pubmed-article:15258591 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15258591 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15258591 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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