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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-8-10
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pubmed:abstractText |
Repulsive guidance molecule (RGM) is an axon guidance protein that repels retinal axons upon activation of the neogenin receptor. To understand the functions of RGM-neogenin complexes in vivo, we used gene transfer technology to perturb their expression in the developing neural tube of chick embryos. Surprisingly, neogenin over-expression or RGM down-expression in the neural tube induces apoptosis. Neogenin pro-apoptotic activity in immortalized neuronal cells and in the neural tube is associated with the cleavage of its cytoplasmic domain by caspases. Thus neogenin is a dependence receptor inducing cell death in the absence of RGM, whereas the presence of RGM inhibits this effect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1465-7392
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
749-55
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15258591-Animals,
pubmed-meshheading:15258591-Apoptosis,
pubmed-meshheading:15258591-Avian Proteins,
pubmed-meshheading:15258591-Caspases,
pubmed-meshheading:15258591-Cell Survival,
pubmed-meshheading:15258591-Cells, Cultured,
pubmed-meshheading:15258591-Chick Embryo,
pubmed-meshheading:15258591-Chickens,
pubmed-meshheading:15258591-Down-Regulation,
pubmed-meshheading:15258591-Enzyme Activation,
pubmed-meshheading:15258591-Gene Expression Regulation, Developmental,
pubmed-meshheading:15258591-Green Fluorescent Proteins,
pubmed-meshheading:15258591-Immunohistochemistry,
pubmed-meshheading:15258591-In Situ Hybridization,
pubmed-meshheading:15258591-Luminescent Proteins,
pubmed-meshheading:15258591-Membrane Proteins,
pubmed-meshheading:15258591-Mutagenesis, Site-Directed,
pubmed-meshheading:15258591-Neurons,
pubmed-meshheading:15258591-RNA, Small Interfering,
pubmed-meshheading:15258591-Rats
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pubmed:year |
2004
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pubmed:articleTitle |
RGM and its receptor neogenin regulate neuronal survival.
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pubmed:affiliation |
UMR CNRS 7102, Université Paris 6, 9 Quai Saint Bernard, 75005 Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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